Results 81 to 90 of about 554,533 (301)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

Media Analysis (MA 95, Print Media)

open access: yes, 1995
The study series ´Media Analyse´ is an annual, systematic survey of media usage among the German population which is conducted by ´Arbeitsgemeinschaft für Media-Analyse (AGMA)“.
Media-Micro-Census, Frankfurt   +1 more
core   +1 more source

Solute transport in aquifers with evolving scale heterogeneity

open access: yesAnalele Stiintifice ale Universitatii Ovidius Constanta: Seria Matematica, 2015
Transport processes in groundwater systems with spatially heterogeneous properties often exhibit anomalous behavior. Using first-order approximations in velocity fluctuations we show that anomalous superdiffusive behavior may result if velocity fields ...
Suciu N.   +6 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Electrical transport in high contrast composite materials [PDF]

open access: yes, 1997
journal articleA broad range of problems in the physics of materials involve highly disordered media whose effective behavior depends critically on the connectedness, or percolation properties of a particular component.
Golden, Kenneth M.   +1 more
core  

MEDIA PEMBELAJARAN TEMATIK “PAPAN ACAK KATA” UNTUK MENINGKATKAN KEMAMPUAN MEMBACA SISWA KELAS VB SD N 2 PADOKAN

open access: yesElementary School, 2019
This study aims to determine the effectiveness of the development of concrete-based learning media "RANDOM WORD BOARD" on the thematic learning system class VBSDN 2 Padokan. The study was conducted based on the current curriculum that uses the concept of
Sukadari Sukadari
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata   +10 more
wiley   +1 more source

Media Analysis (MA 2000, Press Media I)

open access: yes, 2001
The study series "Media Analyse" is an annual, systematic survey of media usage among the German population which is conducted by "Arbeitsgemeinschaft für Media-Analyse (AGMA)“.
Arbeitsgemeinschaft Media-Analyse, Frankfurt am Main   +1 more
core   +2 more sources

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

open access: yesMolecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy   +10 more
wiley   +1 more source

Random walks on Galton-Watson trees with infinite variance offspring distribution conditioned to survive [PDF]

open access: yes, 2008
We establish a variety of properties of the discrete time simple random walk on a Galton-Watson tree conditioned to survive when the offspring distribution, Z say, is in the domain of attraction of a stable law with index alpha is an element of (1,2]. In
Croydon, David A., Kumagai, Takashi
core  

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