Results 71 to 80 of about 489,056 (215)

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

A SIRS Epidemic Model Incorporating Media Coverage with Random Perturbation

Abstract and Applied Analysis, 2013
We investigate the complex dynamics of a SIRS epidemic model incorporating media coverage with random perturbation. We first deal with the boundedness and the stability of the disease—free and endemic equilibria of the deterministic model.
Wenbin Liu
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Numerical Simulation of Intensity Fluctuations in Random Laser Systems [PDF]

Журнал нано- та електронної фізики, 2012
The spectral behavior of a random lasing system (TiO2 powder dispersed in Rhodamine 6 G dye solution) is calculated using numerical calculations. The total integrated intensity is calculated for different incident optical intensities, particle densities,
M.N. Bapat, Anita Sharma
doaj  

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Corrigendum: The behavior of partially coherent twisted space-time beams in atmospheric turbulence

Frontiers in Physics, 2023
Milo Hyde
doaj   +1 more source

Random Phase Screen in Scattering Media with Multi-Parameter Coupling

Photonics
The modeling of light propagation in scattering media is an important topic that has attracted considerable attention in recent decades. Coupling microscopic parameters such as particle concentration, particle size, and the refractive index of the medium
Pengfei Wu, Yixiao Li, Sichen Lei, Jiao Wang, Zhenkun Tan, Tong Zhang, Xiaofan Wang   +6 more
doaj   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Editorial: Applications of wave propagation simulation in complex geological media

Frontiers in Earth Science, 2023
Paul Cupillard, Jonas D. De Basabe
doaj   +1 more source