Results 61 to 70 of about 1,914,522 (244)

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Valores genéticos para as produções de leite do dia do controle e da lactação na raça Holandesa com diferentes modelos estatísticos Breeding values prediction for test day and lactation milk yields in Holstein cattle using different statistical models

Revista Brasileira de Zootecnia, 2007
Foram utilizados 263.390 registros de produção de leite do dia do controle (PDC) de 32.448 primeiras lactações de vacas da raça Holandesa paridas no período de 1991 a 2001 para predizer valores genéticos usando diferentes modelos estatísticos e a ...
Cláudio Manoel Rodrigues de Melo, Irineu Umberto Packer, Claudio Napolis Costa, Paulo Fernando Machado, Mateus Patrício   +4 more
doaj   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Random regression models for genetic evaluation of clinical mastitis in dairy cattle

Animal, 2009
A genetic analysis of longitudinal binary clinical mastitis (CM) data recorded on about 90 000 first-lactation Swedish Holstein cows was carried out using linear random regression models (RRM).
E. Carlén, K. Grandinson, U. Emanuelson, E. Strandberg   +3 more
doaj   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Lactation-wide genetic insights into nitrogen utilization in grazing dairy cows

Journal of Dairy Science
: Societal and economic pressure to reduce nitrogen use in the dairy cow sector is increasing. One potential contributing solution is to breed more nitrogen-efficient dairy cows that excrete less nitrogen.
E. Tavernier, I.C. Gormley, L. Delaby, D.P. Berry   +3 more
doaj   +1 more source

Genetic parameters for test day milk yields of first lactation Holstein cows by random regression models

Animal, 2007
Covariance components for test day milk yield using 263 390 first lactation records of 32 448 Holstein cows were estimated using random regression animal models by restricted maximum likelihood.
C.M.R. de Melo, I.U. Packer, C.N. Costa, P.F. Machado   +3 more
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

On Bayesian inference with conjugate priors for scale mixtures of normal distributions [PDF]

, 2010
Bayesian inference is considered for the multivariate regression model with distribution of the random responses belonging to the multivariate scale mixtures of normal distributions.
Ng, V.M.
core   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source