Results 71 to 80 of about 2,891,219 (304)
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Random independent sets in triangle-free graphs
Forum of Mathematics, SigmaWe establish several new results on the existence of probability distributions on the independent sets in triangle-free graphs where each vertex is present with a given probability.
Anders Martinsson, Raphael Steiner
doaj +1 more source
Comparing spatial regression to random forests for large environmental data sets.
PLoS ONE, 2020 Environmental data may be "large" due to number of records, number of covariates, or both. Random forests has a reputation for good predictive performance when using many covariates with nonlinear relationships, whereas spatial regression, when using ...
Eric W Fox +2 more
doaj +1 more source
Moderate deviation principles for sums of i.i.d. random compact sets [PDF]
, 2009 summary:We prove a moderate deviation principle for Minkowski sums of i.i.d.
Miao, Yu
core +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Depth functions based on a number of observations of a random vector [PDF]
, 2007 We present two statistical depth functions given in terms of the random variable defined as the minimum number of observations of a random vector that are needed to include a fixed given point in their convex hull.
Cascos Fernández, Ignacio
core +1 more source
Sensors, 2019 Under realistic environmental conditions, heuristic-based data association and map management routines often result in divergent map and trajectory estimates in robotic Simultaneous Localization And Mapping (SLAM). To address these issues, SLAM solutions
Diluka Moratuwage +2 more
doaj +1 more source
The Ramanujan Journal, 2015 We study the typical behavior of the size of the ratio set $A/A$ for a random subset $A\subset \{1,\dots , n\}$. For example, we prove that $|A/A|\sim \frac{2\text{Li}_2(3/4)}{π^2}n^2 $ for almost all subsets $A \subset\{1,\dots ,n\}$. We also prove that the proportion of visible lattice points in the lattice $A_1\times\cdots \times A_d$, where $A_i ...
Cilleruelo, Javier +1 more
openaire +2 more sources
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source