Results 41 to 50 of about 698,130 (312)

Biomarker-guided implementation of the KDIGO guidelines to reduce the occurrence of acute kidney injury in patients after cardiac surgery (PrevAKI-multicentre): protocol for a multicentre, observational study followed by randomised controlled feasibility trial [PDF]

, 2020
Introduction Acute kidney injury (AKI) is a frequent complication after cardiac surgery with adverse short-term and long-term outcomes. Although prevention of AKI (PrevAKI) is strongly recommended, the optimal strategy is uncertain.
Arndt, Christian, Campos, Sara, Cegarra Sanmartin, Virginia, Di Prima, Ambra, Forni, Lui, García Álvarez, Mercedes, Gerss, Joachim, Grau Novellas, Neus, Grieshaber, Philippe, Haffner, Michael, Honore, Patrick M, Hoste, Eric A J, Irqsusi, Marc, Italiano, Stefano, Kellum, John, Kunst, Gudrun, Küllmar, Mira, L'acqua, Camilla, Massoth, Christina, Meersch, Melanie, Monaco, Fabrizio, Nair, Shrijit, Ostermann, Marlies, Thomson, Gary, Universitat Autònoma de Barcelona, Vandenberghe, Wim, Weiss, Raphael, Wempe, Carola, Wulf, Hinnerk, Zarbock, Alexander   +29 more
core   +2 more sources

Effect of 12-week shen-based qigong exercise on the residual symptoms of schizophrenia: Study protocol for a single-centre randomised controlled trial

Contemporary Clinical Trials Communications, 2023
Introduction: Negative symptoms and cognitive impairment are common residual symptoms of schizophrenia that seriously affect the quality of life and social function of patients.
Anbei Lian, Qing Fan, Wenzheng Wang, Qinxin Liu, Jiacheng Shi, Min Zhuang, Yujie Li, Xiaodan Liu   +7 more
doaj   +1 more source

Acupuncture in Seasonal Allergic Rhinitis (ACUSAR) - Design and Protocol of a Randomised Controlled Multi-Centre Trial [PDF]

, 2010
Background: We report on the study design and protocol of a randomised controlled trial (Acupuncture in Seasonal Allergic Rhinitis, ACUSAR) that investigates the efficacy of acupuncture in the treatment of seasonal allergic rhinitis (SAR).
Brinkhaus, Benno, Hummelsberger, Josef, Irnich, Dominik, Linde, Klaus, Niggemann, Bodo, Ortiz, Miriam, Pfab, Florian, Reinhold, Thomas, Roll, Stephanie, Wegscheider, Karl, Willich, Stefan N., Witt, Claudia M.   +11 more
core   +1 more source

Contamination in complex healthcare trials:the falls in care homes (FinCH) study experience [PDF]

, 2020
BACKGROUND: Trials are at risk of contamination bias which can occur when participants in the control group are inadvertently exposed to the intervention.
Allen, F, Darby, J, Fox, C, Gordon, A L, Horne, J C, Leighton, P, Logan, P A, Robinson, K, Sims, Erika   +8 more
core   +1 more source

Limitations of randomised controlled trials [PDF]

BMJ, 1995
EDITOR,—T C B Dehn has commented on the problems of accruing patients into randomised controlled trials, noting the understandable reluctance of patients to enter some trials (“I want the best treatment, doctor”) in which the patient's outcome (for example, time to death) is the main end point and, consequently, the patient is unable to benefit from ...
L P, Fielding, R, Grace, R, Hittinger
openaire   +2 more sources

Clinical trial metadata:Defining and extracting metadata on the design, conduct, results and costs of 125 randomised clinical trials funded by the National Institute for Health Research Health Technology Assessment programme [PDF]

, 2015
Background:  By 2011, the Health Technology Assessment (HTA) programme had published the results of over 100 trials with another 220 in progress. The aim of the project was to develop and pilot ‘metadata’ on clinical trials funded by the HTA programme.  
Cook, Andrew, Davidson, Peter, Milne, Ruairidh, Raftery, James, Stanton, Louise, Turner, David, Young, Amanda   +6 more
core   +2 more sources

IJCM_25A: Effect of one-to-one counselling of mothers attending an immunization clinic on breastfeeding among infants- A Randomised Controlled Trial

Indian Journal of Community Medicine
Background: To improve breastfeeding practices, many interventions have been studied at various critical contact points. Our study aimed to improve exclusive breastfeeding by integrating a limited number of counselling sessions with routine immunization ...
Urmimala Maiti, Khan Amir Maroof, S K Bhasin, Dheeraj Shah   +3 more
doaj   +1 more source

A longitudinal assessment of trial protocols approved by research ethics committees: The Adherance to SPIrit REcommendations in the UK (ASPIRE-UK) study

Trials, 2022
Background To assess the quality of reporting of RCT protocols approved by UK research ethics committees before and after the publication of the Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) guideline.
Benjamin Speich, Ayodele Odutayo, Nicholas Peckham, Alexander Ooms, Jamie R. Stokes, Ramon Saccilotto, Dmitry Gryaznov, Belinda von Niederhäusern, Bethan Copsey, Douglas G. Altman, Matthias Briel, Sally Hopewell   +11 more
doaj   +1 more source

A single blind, multicenter, randomized controlled trial to evaluate the effectiveness and cost of a novel nutraceutical (LopiGLIK®) lowering cardiovascular disease risk [PDF]

, 2018
Context: Cardiovascular disease (CVD) costs the economy €210 billion per year in Europe. There is an association between low-density lipoprotein cholesterol (LDL-C) and CVD risk.
Izzo, Raffaele, Manfrin, Andrea, Manzi, Maria Virginia, Rozza, Francesco, Trimarco, Valentina   +4 more
core   +2 more sources

Effect of a machine learning-based severe sepsis prediction algorithm on patient survival and hospital length of stay: a randomised clinical trial. [PDF]

, 2017
IntroductionSeveral methods have been developed to electronically monitor patients for severe sepsis, but few provide predictive capabilities to enable early intervention; furthermore, no severe sepsis prediction systems have been previously validated in
Barton, Christopher W, Das, Ritankar, Feldman, Mitchell D, Mataraso, Samson J, Shimabukuro, David W   +4 more
core   +2 more sources