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Randomization in Clinical Trials
Annals of Internal Medicine, 1987Excerpt To the editor: Stamm and associates (1) address an issue of considerable clinical importance.
W J, Zimmer, J T, Brown, M, Linzer
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Limitations of Randomized Clinical Trials
The American Journal of Cardiology, 2020Randomized clinical trials are essential for determining the efficacy of interventions, but have limitations. The types of limitations discussed in this review may be grouped in 11 categories including incorrect statistical inference, low internal or external validity, misinterpretation of the difference between frequentist and Bayesian statistical ...
John B, Kostis, Jeanne M, Dobrzynski
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The CASSISS Randomized Clinical Trial
Stroke, 2023The CASSISS trial (China Angioplasty & Stenting for Symptomatic Intracranial Severe Stenosis), recently published in JAMA , is the most recent of several randomized controlled trials that have failed to show a benefit of percutaneous angioplasty and stenting over medical therapy for the prevention of stroke due ...
Tanya N. Turan, Marios-Nikos Psychogios
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Randomized Clinical Trials in Surgery
International Journal of Technology Assessment in Health Care, 1989When it is well conducted, a randomized clinical provides the strongest evidence available for evaluating the comparative effectiveness of the interventions tested. Over the last two generations, we have learned much about various devices for strengthening them and about methods of avoiding between in their design, execution, analysis, and reporting ...
B, McPeek, F, Mosteller, M, McKneally
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New England Journal of Medicine, 1972
In 1952, Marc Daniels and Austin Bradford Hill (now Sir Austin) reported that streptomycin combined with para-aminosalicylic acid was more effective than bed rest, or the use of either drug alone, in the therapy of pulmonary tuberculosis in young adults.1 The patients participating in this trial, after they had been accepted on the basis of well ...
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In 1952, Marc Daniels and Austin Bradford Hill (now Sir Austin) reported that streptomycin combined with para-aminosalicylic acid was more effective than bed rest, or the use of either drug alone, in the therapy of pulmonary tuberculosis in young adults.1 The patients participating in this trial, after they had been accepted on the basis of well ...
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