Results 131 to 140 of about 3,612,030 (344)

A framework for Surgical Quality Assurance (SQA) in randomized controlled trials in gastrointestinal surgery: an international Delphi consensus studyResearch in context

EClinicalMedicine
Summary: Background: Randomized controlled trials (RCTs) in gastrointestinal surgery often lack standardized approaches to Surgical Quality Assurance (SQA), which threatens both internal and external validity. The technical complexity and inherent inter-
Dillen C. van der Aa, Sofie P.G. Henckens, Hendrik Jaap Bonjer, Jurriaan B. Tuynman, Marc G. Besselink, Natalie S. Blencowe, Goerge B. Hanna, Mark I. van Berge Henegouwen, Sheraz R. Markar, Suzanne S. Gisbertz   +9 more
doaj   +1 more source

What levels of cholesterol should be treated for primary prevention? [PDF]

, 2002
The levels of cholesterol that should be treated for primary prevention are based on low-density lipoprotein cholesterol (LDL-C) levels of > 100 mg/dL to > 190 mg/dL and vary according to whether the patient's risk is high, moderate, or low.
Meadows, Susan E., Seaton, Terry L.
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Immunogenicity of WHO-17D and Brazilian 17DD yellow fever vaccines: a randomized trial

Revista de Saúde Pública, 2004
OBJECTIVE: To compare the immunogenicity of three yellow fever vaccines from WHO-17D and Brazilian 17DD substrains (different seed-lots). METHODS: An equivalence trial was carried out involving 1,087 adults in Rio de Janeiro.
Camacho Luiz Antonio Bastos, Freire Marcos da Silva, Leal Maria da Luz Fernandes, Aguiar Savitri Gomes de, Nascimento Jussara Pereira do, Iguchi Takumi, Lozana José de Azevedo, Farias Roberto Henrique Guedes   +7 more
doaj  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Meta-analysis of Randomized Controlled Trials

Philippine Journal of Orthopaedics
Background. Anterior cruciate ligament (ACL) injuries are prevalent among younger demographics due to sportsrelated incidents, contributing to knee joint instability.
Leinard Palpal-latoc, Carmelo Braganza
doaj   +1 more source

When do Words Matter? Understanding the Impact of Lexical Choice on Audience Perception using Individual Treatment Effect Estimation

, 2018
Studies across many disciplines have shown that lexical choice can affect audience perception. For example, how users describe themselves in a social media profile can affect their perceived socio-economic status.
Culotta, Aron, Wang, Zhao
core   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Modifiable determinants of older adults’ physical activity and sedentary behavior in community and healthcare settings: a DE-PASS systematic review and meta-analysis

European Review of Aging and Physical Activity
Objectives To identify the modifiable determinants targeted in interventions involving older adults, and to determine which of these interventions effectively increased physical activity (PA) and/or reduced sedentary behaviour (SB).
Simone Ciaccioni, Sofie Compernolle, Maren Lerfald, Federico Palumbo, Floriana Fadda, Ginevra Toma, Selcuk Akpinar, Katja Borodulin, Emine Caglar, Greet Cardon, Murat Cenk Celen, Joanna Cieślińska-Świder, Cristina Cortis, Andrea Di Credico, Murat Emirzeoğlu, Andrea Fusco, Daniel Gallardo Gómez, Linn Marita Hagen, Ayda Karaca, Mohammed Khudair, Marianna De Maio, Paul Jarle Mork, Livia Oddi, Kandianos Emmanouil Sakalidis, Petru Sandu, Sevil Turhan, Wei Wang, Melda Pelin Yargıç, Ekaterina Zotcheva, Laura Capranica, Ciaran MacDonncha, Linda Ernstsen   +31 more
doaj   +1 more source