Results 61 to 70 of about 196,787 (256)
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa +2 more
wiley +1 more source
Bayesian Techniques in Randomized Response
Przegląd Statystyczny. Statistical Review, 2009 The issue of truthfulness of the answers given to socially or personally sensitive questions appeared at the very beginning of the construction of the surveys. The respondents often try to avoid answering a sensitive question or they do not tell the truth.
openaire +1 more source
FEBS Open Bio, EarlyView.This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel +4 more
wiley +1 more source
Characterizing noncompliance in conservation: a multidimensional Randomized Response Technique for multinomial responses [PDF]
, 2018 Rule violation is critical for biological conservation worldwide. Conventional questionnaires are not suitable to survey these violations and specialized questioning techniques that preserve respondents’ privacy, like the forced-response RRT, have been increasingly adopted by conservationists.
Cerri, Jacopo +5 more
openaire +2 more sources
Comment on "Recreational Athletes' Use of Performance‑Enhancing Substances: Results from the First European Randomized Response Technique Survey". [PDF]
Sports Med Open, 2023 Petrou M, Lazuras L.
europepmc +1 more source
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
On the Efficiency of the Newly Developed Composite Randomized Response Technique
Computational and Mathematical MethodsIn today’s data-driven decision-making era, acquiring accurate information is vital. However, survey research faces challenges with sensitive issues. To address this, the Composite Randomized Response Technique (CRRT) was introduced in estimating the ...
Senani P. Dlamini +2 more
doaj +1 more source