Results 71 to 80 of about 11,667,141 (243)

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

A Modified Stratified Randomized Response Techniques [PDF]

, 2014
This paper presents a modification of Kim and Warde’s (2004) Stratified Warner’s Randomized Response Technique (SWRRT) and Kim and Elam’s (2007) Stratified Unrelated Question Randomized Response Technique with known distribution (SURRT) using optimal ...
Johnson, O.O., Adebola, F.B., Adegoke, N.A.   +2 more
core   +1 more source

A novel efficient randomized response model designed for attributes of utmost sensitivity

Heliyon
The existence of potential incomplete truthful reporting emerges when dealing with topics of great sensitivity. This paper introduces a novel, efficient randomized response model to address the challenges of untruthful reporting.
Ahmad M. Aboalkhair, Mohammad A. Zayed, Abdullah H. Al-Nefaie, Mahmaod Alrawad, A.M. Elshehawey   +4 more
doaj   +1 more source

An alternative randomized response model using two deck of cards: a rejoinder

Statistica, 2014
The Randomized response (RR) technique with two decks of cards proposed by Odumade and Singh (2009) can always be made more efficient than the RR techniques proposed by Warner (1965), Mangat and Singh (1990), and Mangat (1994) by adjusting the proportion
Raghunath Arnab, Sarjinder Singh
doaj   +1 more source

Variance estimation using Randomized Response Technique [PDF]

, 2021
The aim of this dissertation is to study the problem of variance estimation for sensitive variables. The problem of variance estimation in the non-sensitive variable case has been well-explored by researchers.
Aloraini, Badr, NC DOCKS at The University of North Carolina at Greensboro   +1 more
core  

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Improving a novel quantitative randomized response method using auxiliary variable information

Heliyon
In the majority of sample surveys, the variable of interest might have sensitive characteristics. Since we frequently get unrealistic responses from respondents during interviews as employing the direct method is not seen logical in these situations.
Hamed Salemian, Eisa Mahmoudi, Osama Abdulaziz Alamri, Javid Shabbir   +3 more
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source