Results 51 to 60 of about 664,509 (315)

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Estimation of Small Area Total with Randomized Data

Revstat Statistical Journal, 2020
In social surveys involving questions that are sensitive or personal in nature, respondents may not provide correct answers to certain questions asked by the interviewer.
Shakeel Ahmed , Javid Shabbir , Sat Gupta , Frank Coolen   +3 more
doaj   +1 more source

The improvement of corn yield and fresh stover weight through two mass selection techniques in dry land

Journal für Kulturpflanzen, 2022
This study aims to determine the response of the yield and fresh stover weight of corn under mass selection by pollination control and base index techniques and to determine the increase in yield and fresh stover after seven mass selection cycles ...
I Wayan Sudika, I Nyoman Soemeinaboedhy
doaj   +1 more source

The Dirichet-Multinomial model for multivariate randomized response data and small samples [PDF]

, 2012
In survey sampling the randomized response (RR) technique can be used to obtain truthful answers to sensitive questions. Although the individual answers are masked due to the RR technique, individual (sensitive) response rates can be estimated when ...
Avetisyan, M., Fox, G.J.A.
core   +1 more source

Sequential monitoring of response-adaptive randomized clinical trials

, 2010
Clinical trials are complex and usually involve multiple objectives such as controlling type I error rate, increasing power to detect treatment difference, assigning more patients to better treatment, and more.
Hu, Feifang, Zhu, Hongjian
core   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Comparison of osseointegration in piezoimplants versus cylindrical implants [PDF]

, 2019
BACKGROUND: Dental implants have been successful for the restoration of edentulous areas, but current techniques are inadequate in areas lacking sufficient bone volume. Piezoelectric surgery has shown encouraging effects on both osseous healing.
Fujinaka, Trevor
core  

A Roadmap for Integrating Neuroscience into Addiction Treatment:A Consensus of the Neuroscience Interest Group of the International Society of Addiction Medicine [PDF]

, 2019
Although there is general consensus that altered brain structure and function underpins addictive disorders, clinicians working in addiction treatment rarely incorporate neuroscience-informed approaches into their practice.
Arunogiri, Shalini, Baldacchino, Alex, Bates, Marsha E., Bowden-Jones, Henrietta, Bruno, Raimondo, Campanella, Salvatore, Daughters, Stacey, Ekhtiari, Hamed, Hester, Rob, Kouimtsidis, Christos, Lorenzetti, Valentina, Lubman, Dan I., Manning, Victoria, Meyerhoff, Dieter J., Moeller, Scott J., Paulus, Martin P., Pennington, David, Piercy, Hugh, Ralph, Annaketurah, Rezapour, Tara, Steele, Douglas, Tavakoli, Hosna, Tolomeo, Serenella, Verdejo-Garcia, Antonio, Zare-Bidoky, Mehran, Zilverstand, Anna   +25 more
core   +6 more sources

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source