Results 91 to 100 of about 4,824,427 (292)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

On random random walks [PDF]

open access: yesThe Annals of Probability, 1996
The author proves a symmetric analog of a theorem due to Dou and Hildebrand on the expected mixing time of certain random walks on a finite group \(G\) of order \(g\) with uniform distribution \(U\), and derives from this result good bounds on diameters of random directed Cayley graphs.
openaire   +3 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Schnorr Randomness

open access: yesElectronic Notes in Theoretical Computer Science, 2002
Abstract.Schnorr randomness is a notion of algorithmic randomness for real numbers closely related to Martin-Löf randomness. After its initial development in the 1970s the notion received considerably less attention than Martin-Löf randomness, but recently interest has increased in a range of randomness concepts.
Downey, Rodney G., Griffiths, Evan J.
openaire   +2 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard   +5 more
wiley   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

open access: yesMolecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck   +12 more
wiley   +1 more source

Stochastic Formulation of Multiscale Model of Hepatitis B Viral Infections

open access: yesMathematics
The study investigates and analyzes certain qualitative properties of a stochastic dynamical multiscale model for hepatitis B viral infection. By formulating appropriate stochastic Lyapunov functions, the study derives sufficient conditions for the ...
Oladele Toyin Ogunfowote   +2 more
doaj   +1 more source

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