Results 61 to 70 of about 157,946 (258)
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Range-Max Queries on Uncertain Data [PDF]
Proceedings of the 35th ACM SIGMOD-SIGACT-SIGAI Symposium on Principles of Database Systems, 2016 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Pankaj K. Agarwal +3 more
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Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Software: Practice and Experience, 2018 SummaryRange minimum query is an important building brick of many compressed data structures and string matching algorithms. Although this problem is essentially solved in theory, with sophisticated data structures allowing for constant time queries, practical performance and construction time also matter.
Tomasz Marek Kowalski, Szymon Grabowski
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Approximate Range Mode and Range Median Queries [PDF]
, 2005 We consider data structures and algorithms for preprocessing a labelled list of length n so that, for any given indices i and j we can answer queries of the form: What is the mode or median label in the sequence of labels between indices i and j. Our results are on approximate versions of this problem.
Prosenjit Bose +3 more
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Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Approximate Range Queries for Clustering
CoRR, 2018 We study the approximate range searching for three variants of the clustering problem with a set $P$ of $n$ points in $d$-dimensional Euclidean space and axis-parallel rectangular range queries: the $k$-median, $k$-means, and $k$-center range-clustering query problems.
Eunjin Oh 0001, Hee-Kap Ahn
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An Efficient Text Interval Hot Word Query Algorithm [PDF]
Jisuanji gongcheng, 2018 Text interval hot word query is based on user-specified query time range,it extracts from the text data hot words.Existing hot words extraction algorithm is generally oriented to mining tasks,which has a high time complexity and is difficult to be ...
ZHAO Zhizhou,LU Chang,HE Zhenying,WANG Xiaoyang
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