Results 131 to 140 of about 196,243 (311)
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Ranking fuzzy numbers using preference ratio: A utility function approach [PDF]
, 2013 Ranking fuzzy numbers is one of the most important phases in any decision making process in fuzzy environments. In most cases, we deal with fuzzy numbers in the field of evaluating alternatives with fuzzy information or linguistic variables.
Soheil Sadi-Nezhad +1 more
core +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Efficiency Criteria and the Sen-type Social Welfare Function [PDF]
Most of the Social Welfare Functions available in the literature are Paretian, that is increase in anybody's income in the society is welfare augmenting. The Sen type social welfare function possesses this property as well.
Pundarik Mukhopadhaya
core
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Ranking Investment Projects [PDF]
This paper describes conditions under which one investment project dominates a second project in terms of net present value, irrespective of the choice of the discount rate.
Foster, James E., Mitra, Tapan
core
Ranking Aggregation Based on Belief Function Theory [PDF]
, 2012 The ranking aggregation problem is that to establishing a new aggregate ranking given a set of rankings of a finite set of items. This problem is met in various applications, such as the combination of user preferences, the combination of lists of ...
Argentini, Andrea
core
Estimation of Survival Function for Rayleigh Distribution by Ranking function:-
مجلة بغداد للعلوم, 2019 In this article, performing and deriving te probability density function for Rayleigh distribution is done by using ordinary least squares estimator method and Rank set estimator method. Then creating interval for scale parameter of Rayleigh distribution.
Hussein et al.
doaj