Results 91 to 100 of about 136,501 (295)

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Social-Aware Edge Caching in Fog Radio Access Networks

IEEE Access, 2017
Fog radio access networks (F-RANs) are becoming an emerging and promising paradigm for fifth generation cellular communication systems. In F-RANs, distributed edge caching techniques among remote radio heads (RRHs) and user equipment (UE) can effectively
Xiang Wang, Supeng Leng, Kun Yang
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Hybrid RANS/LES computation of plane impinging jet flow

Archives of Mechanics, 2011
Flow characteristics are presented of simulation results of plane impinging jets at high nozzle-plate distances, with two k-ω based hybrid RANS/LES (Reynolds Averaged Navier–Stokes/Large–Eddy Simulation) models and a k-ω RANS model. The first hybrid RANS/
S. Kubacki, J. Rokicki, E. Dick
doaj   +1 more source

Ran promotes membrane targeting and stabilization of RhoA to orchestrate ovarian cancer cell invasion [PDF]

, 2019
Kossay Zaoui, Zied Boudhraa, Paul Khalifé, Eurı́dice Carmona, Diane Provencher, Anne‐Marie Mes‐Masson   +5 more
openalex   +1 more source

Session 19. Archiving the Also-Rans: The Value of Defeated Presidential Candidate Papers

, 2021
Sharmila Bhatia, Michael R. Comeau, Alan Delozier, Autumn Haag   +3 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Sketch-To-Solution: An Exploration of Viscous CFD with Automatic Grids [PDF]

Numerical simulation of the Reynolds-averaged NavierStokes (RANS) equations has become a critical tool for the design of aerospace vehicles. However, the issues that affect the grid convergence of three dimensional RANS solutions are not completely ...
Bibb, Karen L., Gomez, Reynaldo J., Kleb, William L., Park, Michael A., Tesch, Steffan H., Thompson, Kyle B., Wood, William A.   +6 more
core   +1 more source

Ran binding protein RanBP1 in zebrafish embryonic development* [PDF]

, 2001
Steve Mangos, Barbara Vanderbeld, Roman Krawetz, Krzysztof Sudol, Gregory M. Kelly   +4 more
openalex   +1 more source