Results 81 to 90 of about 136,501 (295)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Model-Invariant Hybrid RANS-LES Computations on Unstructured Meshes [PDF]

Hybrid RANS-LES computations combine the bene ts of RANS and LES so that LES is used in regions where the accuracy of RANS deteriorates. The numerous hybrid approaches are limited by the speci cation of the LES-RANS interface, which can cause nonphysical
Sreekanth, R., Woodruff, Stephen L.
core   +1 more source

An algebraic model for prediction of bypass and separation-induced transition in turbomachinery boundary layers [PDF]

, 2016
An algebraic intermittency model for bypass and separation-induced transition is presented. The model modifies the production terms of a k-omega turbulence model. It uses only local variables and is tuned for turbomachinery flows.
Dick, Erik, Kubacki, Slawomir
core   +1 more source

Ergodic Capacity Analysis of Remote Radio Head Associations in Cloud Radio Access Networks

, 2014
Characterizing user to Remote Radio Head (RRH) association strategies in cloud radio access networks (C-RANs) is critical for performance optimization.
Peng, Mugen, Poor, H. Vincent, Yan, Shi
core   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Numerical Investigating the Effect of Water Depth on Ship Resistance Using RANS CFD Method

Polish Maritime Research, 2019
On inland waterways the ship resistance and propulsive characteristics are strictly related to the depth of the waterway, thus it is important to have an understanding of the influence of water depth on ship hydrodynamic characteristics.
Hoa Nguyen Thi Ngoc, Bich Vu Ngoc, Tu Tran Ngoc, Chien Nguyen Manh, Hien Le Tat   +4 more
doaj   +1 more source

SIGNIFICANCE OF M1 AND M2 POLARIZATION OF MONOCYTES-MACROPHAGES IN THE BLOOD FOR ATHEROSCLEROSIS RISK ASSESSMENT IN TYPE 2 DIABETES COMPARING WITH CORONARY HEART DISEASE

Российский кардиологический журнал, 2017
Aim. To assess the phenotypes of proinflammatory (M1) and anti-inflammatory (M2) activation of blood monocytes in type 2 diabetes (DM2) comparing to coronary heart disease patients (CHD).Material and methods.
К. О. Galstyan, L. V. Nedosugova, N. G. Nikiforov, К. I. Kolmychkova, Т. V. Kirichenko, I. A. Sobenin   +5 more
doaj   +1 more source

Phytochemical analysis and in-vitro antiurolithiatic properties of selected Malaysian herbs [PDF]

, 2019
The aim of this study was to investigate the phytochemical content of selected Malaysian herbs and their potential antiurolithiatic effects using in-vitro method.
A. Talip, Balkis, Abdul Rahim, Nur Fazira, Abdullah, Norazlin, Abu Bakar, Mohd Fadzelly, Muhammad, Norhayati, Sairi, Nur Halimah, Wan Marzuki Rashidi, Wan Nur Ain Syukriah   +6 more
core  

Entropy-Driven Stochastic Policy for Fast Federated Learning in Beyond 5G Edge-RAN

, 2021
Brahim Aamer, Hatim Chergui, Mustapha Benjillali, Christos Verikoukis   +3 more
openalex   +2 more sources