Results 161 to 170 of about 253,061 (341)

The Mammalian Target of Rapamycin Phosphorylates Sites Having a (Ser/Thr)-Pro Motif and Is Activated by Antibodies to a Region near Its COOH Terminus [PDF]

, 1997
Gregory J. Brunn, Patrick Fadden, Timothy Haystead, John C. Lawrence   +3 more
openalex   +1 more source

On the Discovery of TOR As the Target of Rapamycin

PLOS Pathogens, 2015
Louis Pasteur, who discovered microbes cause disease and developed early vaccines, said, “Chance favors the prepared mind.” With this in mind, I joined the physician-scientist MD-PhD training program at Cornell and Rockefeller Universities in 1984. The National Institutes of Health (NIH) launched the medical scientist training program in 1964 to train ...
openaire   +5 more sources

A Machine‐Learning Approach Identifies Rejuvenating Interventions in the Human Brain

Advanced Science, EarlyView.
Rising life expectancy increases the incidence of age‐related neurodegeneration. Reverting brain aging through effective rejuvenation strategies constitutes a promising strategy to counteract these disorders and restore brain function. This study uses a brain‐specific transcriptional aging clock to screen over 43 000 perturbation profiles, identifying ...
Guillem Santamaria, Cristina Iglesias, Sascha Jung, Javier Arcos Hodar, Ruben Nogueiras, Antonio del Sol   +5 more
wiley   +1 more source

3D‐Printing of Electroconductive MXene‐Based Micro‐Meshes in a Biomimetic Hyaluronic Acid‐Based Scaffold Directs and Enhances Electrical Stimulation for Neural Repair Applications

Advanced Science, EarlyView.
This study combined microscale 3D‐printing with 2D Ti3C2Tx MXene nanosheets to produce electroconductive microfibrous micro‐meshes. By embedding these MXene‐functionalized micro‐meshes within a growth‐supportive macroporous extracellular matrix (ECM)‐based biomaterial, multifunctional biomimetic MXene‐ECM scaffolds were developed.
Ian Woods, Dahnan Spurling, Sandra Sunil, Anne Marie O'Callaghan, Jack Maughan, Javier Gutierrez‐Gonzalez, Tara K. McGuire, Liam Leahy, Adrian Dervan, Valeria Nicolosi, Fergal J. O'Brien   +10 more
wiley   +1 more source

Rapamycin prevents cerebral stroke by modulating apoptosis and autophagy in penumbra in rats [PDF]

, 2018
Bové, Calastretti, Carloni, Castedo, Castedo, Chauhan, Chen, Chong, Chong, Donnan, Ferri, Flynn, Fu, Genova, Harada, Hwang, Hwang, Jiang, Kofman, Koh, Li, Li, Lu, Lu, Maiese, Rieker, Sanghera, Santini, Schmued, Shahjouei, Siddiqui, Thyrell, Urbanek, Wang, Wang, Wechsler, Wong, Xie, Xie, Yang, Yin, Zare, Zeng   +42 more
core   +2 more sources

Unraveling Tissue‐Specific Fatty Acid Biosynthesis and Inter‐Tissue Crosstalk in Mice through Stable‐Isotope Tracing Metabolomics

Advanced Science, EarlyView.
Biosynthesis rates of 13 FFAs are quantitatively calculated in 15 tissues from glucose and an analytical framework to quantitatively calculate inter‐tissue communications of fatty acids between the liver and other tissues is developed. Moreover, the approach is extended to aging condition and a system‐wide decline of fatty acid synthesis in peripheral ...
Beizi Xing, Ruohong Wang, Tianzhang Kou, Wenbin Liu, Zheng‐Jiang Zhu   +4 more
wiley   +1 more source

Pharmacological mTOR inhibitors in ameliorating Alzheimer’s disease: current review and perspectives

Frontiers in Pharmacology
Traditionally, pharmacological mammalian/mechanistic targets of rapamycin (mTOR) kinase inhibitors have been used during transplantation and tumor treatment.
Pei-Lun Xie, Meng-Yu Zheng, Ran Han, Wei-Xin Chen, Jin-Hua Mao   +4 more
doaj   +1 more source

ANTI-CD2 MONOCLONAL ANTIBODIES SYNERGIZE WITH FK506 BUT NOT WITH CYCLOSPORINE OR RAPAMYCIN TO INDUCE TOLERANCE

, 1994
Kenneth D. Chavin, Lihui Qin, Jennifer Woodward, Jixun Lin, Jonathan S. Bromberg   +4 more
openalex   +1 more source

DNase I‐Mediated Chemotactic Nanoparticles for NETs Targeting and Microenvironment Remodeling Treatment of Acute Ischemic Stroke

Advanced Science, EarlyView.
The neutrophil extracellular traps (NETs) play an important role in reperfusion injury in ischemic stroke. Here, considering the unique vascular localization of NETs, a DNase I‐mediated NETs‐targeting nanoparticle is developed to integrate the catalytic and chemotactic functions of DNase I and achieve the synergistic regulation of the internal and ...
Tongyu Zhang, Peixin Liu, Wenru Shen, Chao Li, Zhenhao Zhao, Yuxing Wu, Tao Sun, Chen Jiang   +7 more
wiley   +1 more source

A novel FK506- and rapamycin-binding protein (FPR3 gene product) in the yeast Saccharomyces cerevisiae is a proline rotamase localized to the nucleolus.

, 1994
Bret M. Benton, Jiatao Zang, Jeremy Thorner   +2 more
openalex   +1 more source