Results 171 to 180 of about 164,975 (264)

Geroprotective Effects of Drugs Modulating Metabolic Pathways: Perspectives of Pharmacology in Anti-Aging Therapy. [PDF]

Int J Mol Sci
Grycan M, Zyśk R, Grycan G, Jakiel G, Dudek A, Gromadzka G.   +5 more
europepmc   +1 more source

Absence seizures: Update on signaling mechanisms and networks

Epilepsia Open, EarlyView.
Abstract Absence seizures (AS) are a hallmark of genetic generalized epilepsies (GGE), characterized by brief episodes of impaired consciousness accompanied by electroencephalographic spike‐and‐wave discharges (SWDs). Traditionally attributed to cortico‐thalamo‐cortical (CTC) dysrhythmia, emerging evidence suggests a more intricate pathophysiological ...
Ozlem Akman, Filiz Onat
wiley   +1 more source

Mechanisms of MCM2-7 helicase activation and initial DNA melting at near base-pair resolution. [PDF]

Nat Commun
Weekes C, Willerding L, Khadayate SP, Liebl K, Mossler A, Montoya A, Rauthe V, Karimi MM, Zacharias M, Ulrich HD, Speck C, Reuter LM.   +11 more
europepmc   +1 more source

The multiple hit model of infantile and epileptic spasms: The 2025 update

Epilepsia Open, EarlyView.
Abstract Objective Infantile and epileptic spasms syndrome (IESS) is a developmental and epileptic encephalopathy manifesting with epileptic spasms and poor neurodevelopmental outcomes. There is an urgent need for the development of more effective and tolerated therapies.
Aristea S. Galanopoulou, Wenzhu B. Mowrey, Wei Liu, Anna Maria Katsarou, Qianyun Li, Oleksii Shandra, Solomon L. Moshé   +6 more
wiley   +1 more source

One-step flow synthesis and [⁶⁸Ga]Ga radiolabelling of metal phenolic network nanoparticles for <i>in vivo</i> PET tracking.

Nanoscale
Shepherd E, Carrascal Miniño A, Mishra A, Pellico J, Sengel J, T M de Rosales R, Surman AJ.   +6 more
europepmc   +1 more source

Activation of aryl hydrocarbon receptor by cigarette smoke induces oxidative stress, autophagy impairment and cellular senescence. [PDF]

Tob Induc Dis
Shi BY, Hu XD, Liu YC, Hu SM, Zhang GX.
europepmc   +1 more source

Utility of repeat stereotactic EEG in pediatric patients with tuberous sclerosis

Epilepsia Open, EarlyView.
Abstract Objective Tuberous sclerosis complex (TSC) is a rare genetic disorder associated with early‐onset drug‐resistant epilepsy (DRE) secondary to intracranial tubers. Many patients undergo stereo‐EEG (sEEG) for seizure onset localization, sometimes requiring multiple sEEGs and subsequent epilepsy surgeries. Our objective was to evaluate the effects
Julie Uchitel, Olubunmi Fariyike, Samantha Steeman, Sarah Rockwood, Lily H. Kim, John Choi, Astrid C. Hengartner, Aiden H. Fel, Prathyusha Teeyagura, Gerald Grant, Vivek Buch, Kelly B. Mahaney, Laura M. Prolo, Ann Hyslop Segeren, H. Westley Phillips   +14 more
wiley   +1 more source

Activation of pro-survival autophagy by a small molecule promoting p62 oligomerization. [PDF]

J Biol Chem
Panek J, Fielder E, Sun C, Crabtree S, Kataura T, Wilson N, Baheerathan L, Tang J, Booth L, Yue W, Richardson G, Holder L, Miller GJ, Reynisson J, Sarkar S, Korolchuk VI.   +15 more
europepmc   +1 more source

The genetic architecture of epilepsy across molecular mechanisms and clinical heterogeneity

Epilepsia Open, EarlyView.
Abstract Epilepsy comprises a highly heterogeneous group of neurological disorders unified by a persistent predisposition to recurrent seizures, yet driven by remarkably diverse genetic, molecular, and network‐level mechanisms. Advances in genomic technologies have revealed that epilepsy arises from a multilayered genetic architecture encompassing rare
Mohammad Reza Seyedtaghia, Jina Babanzadeh, Marcello Scala, Lorenzo Perilli, Pasquale Striano   +4 more
wiley   +1 more source

ABA-AA: A simple, reversible, and non-toxic anchor-away system for effective nuclear protein depletion. [PDF]

Cell Rep Methods
Esteban-Serna S, Widén T, Seliner S, Grosemans H, Farquhar I, Swaffer MP, Granneman S.   +6 more
europepmc   +1 more source