Results 231 to 240 of about 255,378 (313)

Above-Filter Digestion Proteomics Reveals Drug Targets and Localizes Ligand Binding Site. [PDF]

J Proteome Res
Sokolova B, Gharibi H, Jafari M, Lyu H, Lovera S, Gaetani M, Saei AA, Zubarev RA.   +7 more
europepmc   +1 more source

White Adipose Tissue Browning and Cross Talk With Metabolic Diseases and Tumors: From Molecular Mechanisms to Clinical Translation

Med Research, EarlyView.
White adipose tissue undergoes browning under endogenous and exogenous stimuli, primarily regulated by core molecules such as PRDM16 and UCP1. It exhibits a double‐edged sword effect in metabolic diseases and tumors: while mitigating metabolic disease impacts and suppressing early‐stage tumors through nutritional competition, it may accelerate cachexia
Yingjiao Wang, Diyuan Zhang, Yuqin Zhou, Ling Qian, Yan Wang, Lei Peng, Min Zhao, Hao Tian, Zhenyu Wu, Aiqi Tang, Minghao Sun, Yi Zhang, Xiaowei Qi   +12 more
wiley   +1 more source

Treatment with rapamycin prevents induction and expression of locomotor sensitization to synthetic cathinone 3,4-methylenedioxypyrovalerone (MDPV) in mice. [PDF]

Forensic Toxicol
Wojcieszak J, Kuczyńska K, Zawilska JB.
europepmc   +1 more source

Nociceptor deletion of Tsc2 enhances axon regeneration by inducing a conditioning injury response in dorsal root ganglia [PDF]

, 2019
Carlin, Dan, Cavalli, Valeria, Ewan, Eric E, Halevi, Alexandra E, Moore, Amy M   +4 more
core   +1 more source

Exercise, exerkines, and muscle–brain crosstalk in Parkinson's disease

Neuroprotection, EarlyView.
Abstract Parkinson's disease (PD) is a progressive neurodegenerative disorder with motor and non‐motor symptoms, driven by dopaminergic loss and α‐synuclein accumulation. Beyond neurodegeneration, growing evidence highlights skeletal muscle health as a key determinant of prognosis, with sarcopenia and frailty contributing to greater disability, fall ...
Salomón Páez‐García, Edgar Alvarado, Alejandro Cuevas, Laura Valverde, Eduardo Salinas, Kevin O'Hara‐Veintimilla, María Cruz Rodríguez‐Oroz, Miguel Germán Borda   +7 more
wiley   +1 more source

Caloric restriction‐mediated reproductive lifespan extension across multiple strains of the clonal aquatic plant Lemna turionifera

Oikos, EarlyView.
Lifespan extension due to caloric restriction (CR) is a well‐established aspect of animal senescence that has been observed in many taxa. Contrastingly, there is much less evidence in plants, even though it is straightforward to manipulate CR by restricting photosynthesis through reduction in light intensity.
Julian A. Ketler, Nicola M. Herman, Suzanne L. Chmilar, Robert A. Laird   +3 more
wiley   +1 more source

Role and mechanism of tetrahedral DNA nanostructures in the repair of urethral injury in rats. [PDF]

Mol Med Rep
Guo C, Li J.
europepmc   +1 more source

Refractory Lung Diseases: From Cellular Structures, Molecular Mechanisms to Therapeutic Strategies

Pediatric Discovery, EarlyView.
ABSTRACT Refractory lung diseases (RLDs) encompass a spectrum of progressive pulmonary disorders, including acute respiratory distress syndrome (ARDS), bronchopulmonary dysplasia (BPD), and idiopathic pulmonary fibrosis (IPF). These conditions are defined by poor responsiveness to current therapeutic interventions and pose substantial clinical ...
Yiheng Qiu, Xiangyu Dong, Yi Zhu, Nicole Miranda, Awele Chukwura, Yan Peng, Sarina Zhao, Michelle Xiang, Peyton McGuire, Ava Zou, Lucas Zhang, Jiaming Fan, Linghuan Zhang   +12 more
wiley   +1 more source

Integration of metabolomics and transcriptomics to reveal metabolic characteristics and the role of mTORC1 in β-cell proliferation induced by a short-term high-fat diet. [PDF]

PeerJ
Wang J, Li J, Li Y, Liu M, Huang S, Li W.   +5 more
europepmc   +1 more source

Alterations in Metabolites Associated With Umbilical Cord Blood in Monozygotic Twins Discordant for Congenital Heart Disease

Pediatric Discovery, EarlyView.
This study found that the metabolomic signature of umbilical venous cord blood in congenital heart disease (CHD) differs from that of healthy monozygotic (MZ) co‐twins. Dysregulation of metabolic pathways like glucose, lipid, and amino acid metabolism, along with altered metabolites, helps understand CHD predisposition.
Fang Xiang, Xiao Yuan, Yi Yang, Philip N. Baker, Mark D. Kilby, Chao Tong, Xi Yuan   +6 more
wiley   +1 more source