Results 231 to 240 of about 315,545 (404)

The Mechanistic Target of Rapamycin (mTOR) Pathway as a Target of Anti-aging Therapies: The Role of Rapamycin and Its Analogs in the Regulation of Cellular Processes and Their Impact on Longevity. [PDF]

Cureus
Zerdka J, Brasse P, Piszka M, Kwapien E, Kubicka M, Bartkowski J, Banach J, Dacyl H, Owczarska A.   +8 more
europepmc   +1 more source

The combination of rapamycin and MAPK inhibitors enhances the growth inhibitory effect on Nara-H cells

, 2014
Osamu Nakamura, Toshiaki Hitora, Yoshiki Yamagami, Masaki Mori, Hideki Nishimura, RYOSUKE HORIE, Konosuke Yamaguchi, Tetsuji Yamamoto   +7 more
openalex   +2 more sources

Rapamycin [PDF]

, 2008
openaire   +1 more source

Raptor, a Binding Partner of Target of Rapamycin (TOR), Mediates TOR Action

Cell, 2002
K. Hara, Y. Maruki, Samuel Long, K. Yoshino, N. Oshiro, Sujuti Hidayat, C. Tokunaga, J. Avruch, K. Yonezawa   +8 more
semanticscholar   +1 more source

Cold atmospheric plasma‐mediated tumor microenvironment remodeling for cancer treatment

BMEMat, EarlyView.
Schematic presentation of CAP‐mediated TME remodeling. This review summarizes recent efforts in cold atmospheric plasma (CAP) application in cancer treatment, highlighting the anticancer potential of CAP, molecular mechanisms, and future perspectives for further improvement and clinical translation.
Israr Khan, Qiujie Fang, Cao Fei, Ziyuan Wang, Zhaowei Chen, Guojun Chen, Zhiming Xu, Shu Xu, Zhitong Chen   +8 more
wiley   +1 more source

Rapamycin preserves cardiac function in autoimmune myocarditis by reprogramming Cxcl9⁺ macrophages via the mTORC1-C/EBPβ-OSM axis. [PDF]

Redox Biol
Zhuang Y, Yan Y, Wen Z, Rao X, Jiang J, Li H, Wang DW.   +6 more
europepmc   +1 more source

Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases

BMEMat, EarlyView.
This review highlights the immunomodulatory potential of nanomaterials (NMs) in treating neurodegenerative diseases (NDs). It focuses on their roles in regulating innate and adaptive immune responses to maintain immune homeostasis. By providing insights into these mechanisms, the review lays the groundwork for innovative NMs therapeutic strategies to ...
Xinru Zhou, Jia Liu, Shulin Lai, Suhan Yin, Bingmin Luo, Longquan Shao, Yiyuan Kang   +6 more
wiley   +1 more source

Rapamycin Modulates the Polarisation of CD4+ T Cells Towards T_H1 Cells in Patients with Active Granulomatosis with Polyangiitis and Microscopic Polyangiitis. [PDF]

J Clin Med
Ha JW, Yoon T, Kwon OC, Park YB, Lee SW.
europepmc   +1 more source

Why we age

Biological Reviews, EarlyView.
ABSTRACT Three categories of explanations exist for why we age: mechanistic theories, which omit reference to evolutionary forces; weakening force of selection theories, which posit that barriers exist that prevent evolutionary forces from optimising fitness in ageing; and optimisation theories, which posit that evolutionary forces actually select for ...
Michael S. Ringel
wiley   +1 more source

Near infrared light controlled gene editing. [PDF]

Light Sci Appl
Berezin MY.
europepmc   +1 more source