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A simple, reversible and non-toxic anchor-away system for effective nuclear depletion of proteins

Esteban-Serna S, Widén T, Grosemans H, Farquhar I, Granneman S.   +4 more
europepmc   +1 more source

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Solubilization of rapamycin

International Journal of Pharmaceutics, 2001
The solubilization of rapamycin, a poorly water soluble investigational immunosuppressive drug, by facilitated hydrotropy is presented. Partially water-miscible aromatic solutes (such as benzyl alcohol, benzoate, or benzoic acid) can be solubilized by water-miscible cosolvents, such as ethanol and propylene glycol.
P, Simamora, J M, Alvarez, S H, Yalkowsky   +2 more
openaire   +2 more sources

Rapamycin (sirolimus, rapamune)

Current Opinion in Nephrology and Hypertension, 1995
Rapamycin is a novel immunosuppressive agent that is undergoing clinical trials for use in allograft rejection therapy. This paper reviews its in-vitro biological properties, the current state of knowledge concerning its mechanism of action, and its therapeutic applications.
S N, Sehgal, J S, Camardo, J A, Scarola, B T, Maida   +3 more
openaire   +2 more sources

IMMUNOPHARMACOLOGY OF RAPAMYCIN

Annual Review of Immunology, 1996
▪ Abstract  The potent immunosuppressive drugs FK506 and rapamycin interfere with signal transduction pathways required for T cell activation and growth. The distinct inhibitory effects of these drugs on the T cell activation program are mediated through the formation of pharmacologically active complexes with members of a family of intracellular ...
R T, Abraham, G J, Wiederrecht
openaire   +2 more sources

Blood distribution of rapamycin

Clinical Biochemistry, 1993
Rapamycin (RAPA) is a potent new immunosuppressive drug. Although blood concentration monitoring of RAPA is being performed in preclinical and clinical trials, little is known regarding the blood distribution of the drug. Such information would have an impact on the medium used for analysis of the drug.
R, Yatscoff, D, LeGatt, R, Keenan, P, Chackowsky   +3 more
openaire   +2 more sources

Rapamycin in cardiovascular medicine

Internal Medicine Journal, 2003
Abstract The cellular action of rapamycin (sirolimus), a natural fermentation product produced by Strepto­myces hygroscopicus, is mediated by binding to the FK506 binding protein. By inhibiting a kinase known as the target of rapamycin, it restricts the proliferation of smooth‐muscle cells by blocking cell‐cycle progression at the G1/S transition.The ...
Ruygrok, PN, Muller, DW, Serruys, PWJC (Patrick)   +2 more
openaire   +3 more sources