Results 271 to 280 of about 315,545 (404)

BCAA (Branched-Chain Amino Acids) Inhibiting the Autophagy System via the Activation of mTORC1, Thereby Upregulating the Tumor Suppressor PDCD4 in Huh7 Hepatoma Cells. [PDF]

Cells
Perveen R, Ozaki I, Takahashi H, Manirujjaman M, Kuwashiro T, Matsuhashi S.   +5 more
europepmc   +1 more source

Rapamycin Attenuates Splenomegaly in both Intrahepatic and Prehepatic Portal Hypertensive Rats by Blocking mTOR Signaling Pathway

, 2016
Yunyang Chen, Weijie Wang, Huakai Wang, Yongjian Li, Minmin Shi, Hongwei Li, Jiqi Yan   +6 more
openalex   +2 more sources

Mechanisms of spinal glial activation in chemotherapy‐induced peripheral neuropathy: Focus on microglia and astrocytes

Ibrain, EarlyView.
Chemotherapy‐induced peripheral neuropathy (CIPN) remains a major clinical challenge, with central sensitization considered an important pathological mechanism in its occurrence and persistence. This review focuses on spinal astrocytes and microglia, systematically summarizing the pathological mechanisms of spinal glial cells involved in CIPN caused by
Long Gu, Song Cao, Yonghuai Feng
wiley   +1 more source

Depletion of individual dietary amino acids induce distinct metabolic and chromatin states. [PDF]

J Biol Chem
Haws SA, Liu Y, Green CL, Chaiyakul K, Mishra P, Babygirija R, Armstrong EA, Mehendale AT, Ong IM, Lamming DW, Denu JM.   +10 more
europepmc   +1 more source

Interleukin 2 stimulation of p70 S6 kinase activity is inhibited by the immunosuppressant rapamycin.

, 1992
Víctor Calvo, Craig M. Crews, Terry A. Vik, Barbara E. Bierer   +3 more
openalex   +2 more sources

Surface Engineering of Porous Silicon Microparticles for Intravitreal Sustained Delivery of Rapamycin [PDF]

, 2015
Alejandra Nieto, Huaming Hou, Sung-Won Moon, Michael J. Sailor, William R. Freeman, Lingyun Cheng   +5 more
openalex   +1 more source

A randomized controlled trial to establish effects of short-term rapamycin treatment in 24 middle-aged companion dogs

GeroScience, 2017
Silvan R. Urfer, T. Kaeberlein, S. Mailheau, P. Bergman, Kate E. Creevy, D. Promislow, M. Kaeberlein   +6 more
semanticscholar   +1 more source

Efficacy, safety, and relapse outcomes of MAPK inhibitors in pediatric Langerhans cell histiocytosis: A real‐world study

International Journal of Cancer, EarlyView.
What's new? Mitogen‐activated protein kinase (MAPK) inhibitors are promising treatments for pediatric Langerhans cell histiocytosis (LCH), a rare heterogeneous neoplasm that often affects multiple organ systems. Which MAPK inhibitors are most effective against LCH remains uncertain.
Xue Tang, Jing‐jing Sun, Zhi Wan, Xiao‐yu Jing, Xia Guo, Ju Gao   +5 more
wiley   +1 more source

mTOR signaling networks: mechanistic insights and translational frontiers in disease therapeutics. [PDF]

Signal Transduct Target Ther
Zhang H, Xiao X, Pan Z, Dokudovskaya S.
europepmc   +1 more source

Rapamycin's sister [PDF]

Nature Methods, 2012
openaire   +1 more source