Results 291 to 300 of about 315,545 (404)

Inflammatory bowel disease and metabolic reprogramming: From pathological mechanisms to targeted interventions

Interdisciplinary Medicine, EarlyView.
This review explores the role of metabolic reprogramming in inflammatory bowel disease (IBD) by focusing on immune and epithelial cell metabolism, microbial metabolites, and their impact on inflammation. It discusses emerging metabolic therapies and emphasizes the importance of personalized microbiota‐targeted approaches to improve clinical outcomes in
Zemin Tian, Yinde Huang, Ying Wang, Chenyu Zhao, Zhaokai Zhou, Hua Yang, Yuan Qiu   +6 more
wiley   +1 more source

Treatment with L-type amino acid transporter 1 inhibitor JPH203 enhances protein synthesis in C2C12 myotubes. [PDF]

Sci Rep
Takegaki J, Saneyasu T, Honda K.
europepmc   +1 more source

Cell Toxicity and Autophagy in A549 Cells Treated With Surface‐Functionalized Graphene Derivatives

Journal of Applied Toxicology, EarlyView.
ABSTRACT Graphene oxide and its derivatives have unique physical and chemical properties with applications in many different fields. However, their biological effects and mechanisms of intracellular toxicity have not been completely clarified. In this study, we investigated the cytotoxic and autophagic activities of graphene oxide and its derivatives ...
Tae Yun Park, Soo Young Kim, Chang Seok Park, Won Young Kim, Jae‐Woo Jung, Jae‐Yeol Kim, Jong Wook Shin   +6 more
wiley   +1 more source

Mitochondrial metabolic rewiring sensitizes mTORC1 inhibitor persister cells to cuproptosis. [PDF]

JCI Insight
Du H, Liu HJ, Losko M, Yang YC, Yuan M, Henske EP, Asara JM, Singh M, Kwiatkowski DJ.   +8 more
europepmc   +1 more source

Endoplasmic Reticulum and Golgi Localization Sequences for Mammalian Target of Rapamycin

, 2007
Xiangyu Liu, Xiao-Feng Zheng
openalex   +1 more source

Surviving rapamycin

The Journal of Experimental Medicine, 2005
openaire   +2 more sources

Impact of organic pollutants on phenotype and gene expression in human breast cancer cells

Journal of Applied Toxicology, EarlyView.
ABSTRACT Human exposure to industrial chemical compounds is widespread and, although often beneficial, prolonged contact may contribute to disease development, including cancer. While many studies have shown organic pollutants (OP) are cytotoxic, few have explored how long‐term exposure alters cell phenotype.
Camila Confortin, Heloisa Amancio, Jessica Zablocki da Luz, Aliciane de Almeida Roque, Tugstênio Lima de Souza, José Eduardo Vargas, Ciro Alberto de Oliveira Ribeiro, Francisco Filipak Neto   +7 more
wiley   +1 more source

Reprogramming chemically induced dimerization systems with genetically encoded nanobodies. [PDF]

Chem Sci
Wang T, Nonomura T, Cui M, Lan TH, Cai PX, He L, Zhou Y.   +6 more
europepmc   +1 more source

Mechanical loading induces the longitudinal growth of muscle fibers via a rapamycin-insensitive mechanism

Hibbert, Jamie, Jorgenson, Kent, Sayed, Ramy, Paez, Hector, Meinhold, Marius, Flynn, Corey, Lange, Anthony, Lindley, Garrison, Flejsierowicz, Philip, Hornberger, Troy   +9 more
openalex   +1 more source

Artificial intelligence strategies for predicting kinase inhibitor resistance: A comprehensive review of methods, challenges, and future perspectives

Journal of Intelligent Medicine, EarlyView.
Abstract Kinase inhibitors are essential in targeted cancer therapy, yet resistance often emerges through secondary mutations, activation of compensatory signaling pathways, or drug‐efflux mechanisms. Artificial intelligence (AI) provides a workflow‐based strategy rather than a list of unrelated tools for predicting and addressing kinase‐inhibitor ...
Faris Hassan, Mohanad Ali Deifallah, Alaa Zaghloul, Rania Elgohary   +3 more
wiley   +1 more source