Results 301 to 310 of about 315,545 (404)

Inducible chromosomal rearrangement reveals nonlinear polygenic dosage effects in driving aneuploid yeast traits. [PDF]

Nat Commun
Yin H, Guo Z, Zhou C, Ma L, Wu Y, Yuan YJ.   +5 more
europepmc   +1 more source

Biomarkers for the estimation of isoproterenol‐induced myocardial infarction: A review of key parameters

Journal of Intelligent Medicine, EarlyView.
Abstract The isoproterenol‐induced myocardial infarction model is a well‐established experimental approach for studying cardiac injury and testing potential protective treatments. By overstimulating beta‐adrenergic receptors, this model closely reproduces key features of human heart attacks, including oxidative damage, calcium imbalance, inflammatory ...
Bushra Imran, Tarique Mahmood, Farogh Ahsan, Shahzadi Bano, Vaseem Ahamad Ansari, Mohd Adnan   +5 more
wiley   +1 more source

Growth factor-independent mTORC1 signaling promotes primary cilia length via suppression of autophagy. [PDF]

iScience
Shin J, Tighanimine K, Cormerais Y, Rosenthal DM, Niroula P, Lapp SC, Kalafut KC, Cisse MY, Schrötter S, Manning BD.   +9 more
europepmc   +1 more source

Epigenetic inflammatory memory and periodontal disease: Mechanisms and clinical significance for comorbidities

Journal of Periodontology, EarlyView.
Abstract Historically, immunological memory was considered an exclusive feature of adaptive immunity. However, innate immune cells have recently been shown to record and maintain epigenetically imprinted memory of earlier infectious or inflammatory challenges.
George Hajishengallis
wiley   +1 more source

Macrophages lacking TSC2 have mTORC1-dependent increased GPNMB and ameliorate ventricular dysfunction/remodeling after ischemia-reperfusion. [PDF]

Sci Rep
Keykhaei M, Koleini N, Meddeb M, Polhemus DJ, Tajdini M, Rezaee M, Huang Q, Panesar T, Ranek MJ, Adamo L, Kass DA.   +10 more
europepmc   +1 more source

Juvenile polyposis in a SMAD4‐mutated child: A call for early surveillance

JPGN Reports, EarlyView.
Abstract We report the case of a 10‐year‐old boy with hereditary hemorrhagic telangiectasia (HHT) and a family history of SMAD4‐related juvenile polyposis syndrome (JPS), presenting with hypoferritinaemia unresponsive to oral supplementation. Endoscopic evaluation revealed multiple gastrointestinal polyps, including duodenal, gastric, and colonic ...
Claudia Lorusso, Giuseppe Lassandro, Stefania Castellaneta, Valentina Palladino, Giovanni la Grasta, Vanessa Nadia Dargenio, Vittorio Labriola, Alberto Gaeta, Paola Giordano, Fernanda Cristofori, Ruggiero Francavilla   +10 more
wiley   +1 more source

Direct modulation of TRPM8 ion channels by rapamycin and analog macrolide immunosuppressants. [PDF]

Elife
Tóth BI, Bazeli B, Janssens A, Lisztes E, Racskó M, Kelemen B, Herczeg M, Nagy TM, Kövér KE, Mitra A, Borics A, Bíró T, Voets T.   +12 more
europepmc   +1 more source

肺リンパ脈管筋腫症におけるIntracrine機構による性ステロイドホルモン産生とmammalian target of rapamycin(mTOR)シグナル経路の発現

, 2015
厚子 安達
openalex   +1 more source

BMI and Breast Subcutaneous Fat

Journal of Ultrasound in Medicine, EarlyView.
Objectives Obesity is closely associated with the occurrence and progression of breast cancer. While body mass index (BMI) is widely used to diagnose obesity, it has certain limitations. Subcutaneous fat thickness (SFT) also serves as an indicator of body composition. However, studies on breast SFT are scarce.
Shiyu Wang, Jin Zhou, Yunxia Huang, Dongdong Zheng, Ruoqing Hou, Shichong Zhou   +5 more
wiley   +1 more source

GLIS2 Promotes Epithelial‐Mesenchymal Transition and Gastric Cancer Progression by Regulating BGN to Activate the Wnt/β‐Catenin Pathway

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT This study elucidates the mechanism by which GLIS Family Zinc Finger 2 (GLIS2) promotes epithelial‐mesenchymal transition (EMT) in gastric cancer through biglycan (BGN) activation and Wnt/β‐catenin stimulation. By analyzing 18 pairs of GC tissues and establishing in vitro models (combining GLIS2 knockdown/BGN overexpression with Wnt pathway ...
Juan Yan, Ya‐Peng Deng
wiley   +1 more source