Results 51 to 60 of about 315,545 (404)

Alleviation of cisplatin-induced neuropathic pain, neuronal apoptosis, and systemic inflammation in mice by rapamycin

Frontiers in Aging Neuroscience, 2022
Platinum-based chemotherapeutic treatment of cancer patients is associated with debilitating adverse effects. Several adverse effects have been well investigated, and can be managed satisfactorily, but chemotherapy-induced peripheral neuropathy (CIPN ...
Moureq Alotaibi, Faten Al-Aqil, Faleh Alqahtani, Miteb Alanazi, Ahmed Nadeem, Sheikh F. Ahmad, Rebeca Lapresa, Rebeca Lapresa, Metab Alharbi, Abdulrahman Alshammari, Muteb Alotaibi, Tareq Saleh, Raed Alrowis   +12 more
doaj   +1 more source

Pharmacological mTOR inhibitors in ameliorating Alzheimer’s disease: current review and perspectives

Frontiers in Pharmacology
Traditionally, pharmacological mammalian/mechanistic targets of rapamycin (mTOR) kinase inhibitors have been used during transplantation and tumor treatment.
Pei-Lun Xie, Meng-Yu Zheng, Ran Han, Wei-Xin Chen, Jin-Hua Mao   +4 more
doaj   +1 more source

PRAS40 suppresses atherogenesis through inhibition of mTORC1-dependent pro-inflammatory signaling in endothelial cells [PDF]

, 2019
Endothelial pro-inflammatory activation plays a pivotal role in atherosclerosis, and many pro-inflammatory and atherogenic signals converge upon mechanistic target of rapamycin (mTOR).
Althoff, Till F., Burghaus, Jana, Cao Ho, Thanh, Jürgensen, Lonny, Kamuf-Schenk, Verena, Katus, Hugo A., Kiper, Leon, Krull, Alexandros, Riechert, Eva, Schecker, Johannes, Stangl, Karl, Stangl, Verena, Völkers, Mirko, Wöltje, Kerstin, Zhang, Kevin Sun   +14 more
core   +1 more source

Rapamycin Attenuated Zinc-Induced Tau Phosphorylation and Oxidative Stress in Rats: Involvement of Dual mTOR/p70S6K and Nrf2/HO-1 Pathways

Frontiers in Immunology, 2022
Alzheimer’s disease is pathologically characterized by abnormal accumulation of amyloid-beta plaques, neurofibrillary tangles, oxidative stress, neuroinflammation, and neurodegeneration.
Chencen Lai, Chencen Lai, Zhuyi Chen, Yuanting Ding, Qian Chen, Songbai Su, Heng Liu, Ruiqing Ni, Ruiqing Ni, Zhi Tang   +9 more
doaj   +1 more source

Intranasal rapamycin ameliorates Alzheimer-like cognitive decline in a mouse model of Down syndrome [PDF]

, 2018
Background: Down syndrome (DS) individuals, by the age of 40s, are at increased risk to develop Alzheimer-like dementia, with deposition in brain of senile plaques and neurofibrillary tangles.
Arena, Andrea, Barone, Eugenio, Blarzino, Carla, Butterfield, D. Allan, Di Domenico, Fabio, Lanzillotta, Chiara, Mosca, Luciana, Perluigi, Marzia, Tramutola, Antonella, Zuliani, Ilaria   +9 more
core   +3 more sources

Rapamycin regulates the balance between cardiomyocyte apoptosis and autophagy in chronic heart failure by inhibiting mTOR signaling

International Journal of Molecular Medicine, 2019
The progressive loss of cardiomyocytes caused by cell death leads to cardiac dysfunction and heart failure (HF). Rapamycin has been shown to be cardioprotective in pressure-overloaded and ischemic heart diseases by regulating the mechanistic target of ...
Guangyuan Gao, Weiwei Chen, M. Yan, Jinsha Liu, Huiling Luo, Chang Wang, Ping Yang   +6 more
semanticscholar   +1 more source

Loss of ATF3 exacerbates liver damage through the activation of mTOR/p70S6K/ HIF-1α signaling pathway in liver inflammatory injury. [PDF]

, 2018
Activating transcription factor 3 (ATF3) is a stress-induced transcription factor that plays important roles in regulating immune and metabolic homeostasis.
Jiang, Bin, Jiang, Longfeng, Ke, Bibo, Li, Changyong, Lu, Ling, Ni, Xuhao, Wang, Han, Wang, Xuehao, Zhang, Feng, Zhu, Qiang   +9 more
core   +2 more sources

Topical rapamycin reduces markers of senescence and aging in human skin: an exploratory, prospective, randomized trial

GeroScience, 2019
Aging is a major risk factor for the majority of human diseases, and the development of interventions to reduce the intrinsic rate of aging is expected to reduce the risk for age-related diseases including cardiovascular disease, cancer, and dementia. In
C. L. Chung, Ibiyonu Lawrence, M. Hoffman, Dareen Elgindi, Kumar S. Nadhan, Manali Potnis, Annie Jin, Catlin Sershon, Rhonda Binnebose, A. Lorenzini, C. Sell   +10 more
semanticscholar   +1 more source

Next-Generation Drugs and Probes for Chromatin Biology: From Targeted Protein Degradation to Phase Separation

Molecules, 2018
Chromatin regulation is a critical aspect of nuclear function. Recent advances have provided detailed information about dynamic three-dimensional organization of chromatin and its regulatory factors.
Katerina Cermakova, H. Courtney Hodges
doaj   +1 more source

Ornithine Decarboxylase mRNA is Stabilized in an mTORC1-dependent Manner in Ras-transformed Cells [PDF]

, 2012
Upon Ras activation, ODC (ornithine decarboxylase) is markedly induced, and numerous studies suggest that ODC expression is controlled by Ras effector pathways. ODC is therefore a potential target in the treatment and prevention of Ras-driven tumours. In
Albig, Barreau, Bhattacharyya, Carracedo, Eulalio, Feith, Feith, Foat, Garneau, Gerner, Grens, Ito, Jacinto, Jian-Ying Wang, Johannes, Kashiwagi, Katsanou, Kawai, Kawai, Kedersha, Kertesz, Lai, Lal, Lan Xiao, Liao, Lisa M. Shantz, Liu, Lorenzini, Manzella, Marderosian, Mazan-Mamczarz, Nowotarski, Origanti, Proud, Rao, Repasky, Rousseau, Sarbassov, Shannon L. Nowotarski, Shantz, Shantz, Sofia Origanti, Song, Suswam, Suzanne Sass-Kuhn, Svitkin, Theresa D. Carr, Tong, Topisirovic, Zhang, Zou, Zou   +51 more
core   +2 more sources