Results 31 to 40 of about 257,231 (311)

A strategy to combine pathway-targeted low toxicity drugs in ovarian cancer. [PDF]

, 2015
Serous Ovarian Cancers (SOC) are frequently resistant to programmed cell death. However, here we describe that these programmed death-resistant cells are nonetheless sensitive to agents that modulate autophagy.
Bartakova, Alena, Davis, Mitzie-Ann, Delaney, Joe R, Haft, Carley, Lu, Dan, McCabe, Katelyn E, Patel, Chandni, Schlaepfer, David D, Stupack, Dwayne G, Tancioni, Isabelle, von Schalscha, Tami   +10 more
core   +2 more sources

COVID 19 in a family with rare genetic disease of the nervous system

Неврология, нейропсихиатрия, психосоматика, 2022
We present familial tuberous sclerosis (TS) case complicated by COVID-19. COVID-19 aggravates the course of TS and may lead to a fatal outcome. We review the role of mTORC1 (mechanistic/mammalian Target of Rapamycin Complex 1) in the development and ...
M. Yu. Martynov, V. A. Kutashov, O. V. Ulyanova   +2 more
doaj   +1 more source

Placental DEPTOR as a stress sensor during pregnancy [PDF]

, 2011
The author(s) has paid for this article to be freely available under the terms of the Creative Commons Attribution Non-Commercial Licence (http://creativecommons.org/licenses/by-nc/2.5/) which permits unrestricted non-commercial use, distribution and ...
Gidron, Y, Goumenou, A, Karteris, E, Mparmpakas, D, Zachariades, E   +4 more
core   +2 more sources

Next-Generation Drugs and Probes for Chromatin Biology: From Targeted Protein Degradation to Phase Separation

Molecules, 2018
Chromatin regulation is a critical aspect of nuclear function. Recent advances have provided detailed information about dynamic three-dimensional organization of chromatin and its regulatory factors.
Katerina Cermakova, H. Courtney Hodges
doaj   +1 more source

Enhancement of the Tolerogenic Phenotype in the Liver by ImmTOR Nanoparticles

Frontiers in Immunology, 2021
ImmTOR biodegradable nanoparticles encapsulating rapamycin have been shown to induce a durable tolerogenic immune response to co-administered biologics and gene therapy vectors.
Petr O. Ilyinskii, Christopher J. Roy, Julie LePrevost, Gina L. Rizzo, Takashi Kei Kishimoto   +4 more
doaj   +1 more source

Vacuolating cytotoxin and variants in Atg16L1 that disrupt autophagy promote Helicobacter pylori infection in humans [PDF]

, 2012
Peer ...
Alberto Delgado, Amieva, Argent, Barrett, Cathy Streutker, Dana J. Philpott, Deepa Raju, Deretic, El-Omar, Emad El Omar, Erdmutte Kunstmann, Esther Galindo–Mata, Franco, Georgina Hold, Gonzalez, Gutierrez, Heidi Mascarenhas, Iwamaru, Jia, Judith Romero–Gallo, Kimura, Kirkegaard, Kuballa, Lapaquette, Levine, Luther, Luther, Mahendra Singh Ramjeet, Maiuri, Mark S. Silverberg, Mathew, Mathew, Mauricio R. Terebiznik, Michal Sibony, Michelle Ang, Mortimore, Moscat, Nicola L. Jones, Ogawa, Ogawa, Orvedahl, Pelayo Correa, Polk, Richard M. Peek, Rioux, Saitoh, Satin, Scott, Seamus Hussey, Stephen E. Girardin, Steven R. Blanke, Tamotsu Yoshimori, Tanida, Terebiznik, Terebiznik, Travassos, Vijay Gupta, Wang, White, Yoshimori, Zheng, Zheng   +61 more
core   +1 more source

Neuroprotective effect of rapamycin on spinal cord injury via activation of the Wnt/β-catenin signaling pathway

Neural Regeneration Research, 2015
The Wnt/β-catenin signaling pathway plays a crucial role in neural development, axonal guidance, neuropathic pain remission and neuronal survival. In this study, we initially examined the effect of rapamycin on the Wnt/β-catenin signaling pathway after ...
Kai Gao, Yan-song Wang, Ya-jiang Yuan, Zhang-hui Wan, Tian-chen Yao, Hai-hong Li, Pei-fu Tang, Xi-fan Mei   +7 more
doaj   +1 more source

Role of mTOR signaling in tumor microenvironment. An overview [PDF]

, 2018
The mammalian target of rapamycin (mTOR) pathway regulates major processes by integrating a variety of exogenous cues, including diverse environmental inputs in the tumor microenvironment (TME).
Bazzichetto, Chiara, Bria, Emilio, Ciuffreda, L., Cognetti, F., COGNETTI, FRANCESCO, Conciatori, Fabiana, Falcone, I., Milella, M., Pilotto, Sara   +8 more
core   +2 more sources

Pharmacological mTOR inhibitors in ameliorating Alzheimer’s disease: current review and perspectives

Frontiers in Pharmacology
Traditionally, pharmacological mammalian/mechanistic targets of rapamycin (mTOR) kinase inhibitors have been used during transplantation and tumor treatment.
Pei-Lun Xie, Meng-Yu Zheng, Ran Han, Wei-Xin Chen, Jin-Hua Mao   +4 more
doaj   +1 more source

Rapamycin Exacerbates Staphylococcus aureus Pneumonia by Inhibiting mTOR-RPS6 in Macrophages

Journal of Inflammation Research, 2023
Fang-Yi Yu,* Kua Zheng,* Yin-Fang Wu,* Shen-Wei Gao, Qing-Yu Weng, Chen Zhu, Yan-Ping Wu, Miao Li, Zhong-Nan Qin, Jia-Fei Lou, Zhi-Hua Chen, Song-Min Ying, Hua-Hao Shen, Wen Li Key Laboratory of Respiratory Disease of Zhejiang Province ...
Yu FY, Zheng K, Wu YF, Gao SW, Weng QY, Zhu C, Wu YP, Li M, Qin ZN, Lou JF, Chen ZH, Ying SM, Shen HH, Li W   +13 more
doaj