Results 31 to 40 of about 159,720 (266)

Effects of low-dose rapamycin on lymphoid organs of mice prone and resistant to accelerated senescence

Frontiers in Immunology
Aging is a complex, natural, and irreversible phenomenon that subjects the body to numerous changes in the physiological process, characterized by a gradual decline in the organism’s homeostatic mechanisms, closely related to immunosenescence.
Rafael dos Santos Barros, Luiz Adriano Damasceno Queiroz, Josiane Betim de Assis, Kamilla Costa Pantoja, Sofia Xavier Bustia, Emanuella Sarmento Alho de Sousa, Stephen Fernandes Rodrigues, Eliana Hiromi Akamine, Anderson Sá-Nunes, Joilson O. Martins   +9 more
doaj   +1 more source

Rapamycin inhibits cardiac hypertrophy by promoting autophagy via the MEK/ERK/Beclin-1 pathway

Frontiers in Physiology, 2016
Rapamycin, also known as sirolimus, is an antifungal agent and immunosuppressant drug used to prevent organ rejection in transplantation. However, little is known about the role of rapamycin in cardiac hypertrophy and the signaling pathways involved ...
Changqian eWang, Gu eJun, Gu eJun, Wei eHu, Zhi-ping eSong, Yue-guang eChen, Da-dong eZhang   +6 more
doaj   +1 more source

Inflammation Is More Sensitive than Cell Proliferation in Response to Rapamycin Treatment in Polycystic Kidney Disease

Kidney & Blood Pressure Research
Introduction: It has been reported that rapamycin inhibited inflammation in renal interstitial diseases. We therefore hypothesized that rapamycin could attenuate inflammation in polycystic kidney disease (PKD).
Ming Yang, Jiayi Lv, Chanjuan Gong, Cheng Xue, Lili Fu, Shunjie Chen, Changlin Mei   +6 more
doaj   +1 more source

Longevity, aging and rapamycin [PDF]

Cellular and Molecular Life Sciences, 2014
The federal drug administration (FDA)-approved compound rapamycin was the first pharmacological agent shown to extend maximal lifespan in both genders in a mammalian species. A major question then is whether the drug slows mammalian aging or if it has isolated effects on longevity by suppressing cancers, the main cause of death in many mouse strains ...
Ehninger, Dan, Neff, Frauke, Xie, Kan
openaire   +3 more sources

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Characteristics and outcomes of patients with LAM receiving sirolimus in France based on real-life data

Frontiers in Medicine
LAM is a rare multi-cystic lung disease for which treatment with sirolimus is indicated in cases of moderate or severe lung disease or declining lung function.
Vincent Cottin, Vincent Cottin, Antoine Cases, Virginie Bourdin, Martine Reynaud-Gaubert, Sandrine Hirschi, Mallorie Kerjouan, Rémi Diesler, Rémi Diesler, Brieux Chardès, Stéphane Fiévez, Nada Assi, Aurélie Schmidt, Hélène Denis, Lidwine Wémeau-Stervinou, Yurdagul Uzunhan   +15 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Repurposing Proteostasis-Modifying Drugs to Prevent or Treat Age-Related Dementia: A Systematic Review

Frontiers in Physiology, 2018
Background: Dementia has a significant impact on quality of life of older individuals. Impaired proteostasis has been implicated as a potential cause of dementia, that can be therapeutically targeted to improve patient outcomes.
Daniel S. Heard, Camilla S. L. Tuttle, Nicola T. Lautenschlager, Nicola T. Lautenschlager, Andrea B. Maier, Andrea B. Maier   +5 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

New insights into tuberous sclerosis complex: from structure to pathogenesis

Frontiers in Cell and Developmental Biology
Tuberous sclerosis complex is a genetic disorder characterised by the formation of benign tumours in multiple organs, primarily due to pathogenic variants in the TSC1 and TSC2 tumour suppressor genes. These genes encode hamartin and tuberin, respectively,
Chao-Sheng Chen, Christopher H. S. Aylett   +1 more
doaj   +1 more source