Results 21 to 30 of about 159,720 (266)

Rapamycin: Drug Repurposing in SARS-CoV-2 Infection

Pharmaceuticals, 2021
Since December 2019, SARS-CoV-2 (COVID-19) has been a worldwide pandemic with enormous consequences for human health and the world economy. Remdesivir is the only drug in the world that has been approved for the treating of COVID-19.
Jiri Patocka, Kamil Kuca, Patrik Oleksak, Eugenie Nepovimova, Martin Valis, Michal Novotny, Blanka Klimova   +6 more
doaj   +1 more source

COVID 19 in a family with rare genetic disease of the nervous system

Неврология, нейропсихиатрия, психосоматика, 2022
We present familial tuberous sclerosis (TS) case complicated by COVID-19. COVID-19 aggravates the course of TS and may lead to a fatal outcome. We review the role of mTORC1 (mechanistic/mammalian Target of Rapamycin Complex 1) in the development and ...
M. Yu. Martynov, V. A. Kutashov, O. V. Ulyanova   +2 more
doaj   +1 more source

Next-Generation Drugs and Probes for Chromatin Biology: From Targeted Protein Degradation to Phase Separation

Molecules, 2018
Chromatin regulation is a critical aspect of nuclear function. Recent advances have provided detailed information about dynamic three-dimensional organization of chromatin and its regulatory factors.
Katerina Cermakova, H. Courtney Hodges
doaj   +1 more source

Enhancement of the Tolerogenic Phenotype in the Liver by ImmTOR Nanoparticles

Frontiers in Immunology, 2021
ImmTOR biodegradable nanoparticles encapsulating rapamycin have been shown to induce a durable tolerogenic immune response to co-administered biologics and gene therapy vectors.
Petr O. Ilyinskii, Christopher J. Roy, Julie LePrevost, Gina L. Rizzo, Takashi Kei Kishimoto   +4 more
doaj   +1 more source

Neuroprotective effect of rapamycin on spinal cord injury via activation of the Wnt/β-catenin signaling pathway

Neural Regeneration Research, 2015
The Wnt/β-catenin signaling pathway plays a crucial role in neural development, axonal guidance, neuropathic pain remission and neuronal survival. In this study, we initially examined the effect of rapamycin on the Wnt/β-catenin signaling pathway after ...
Kai Gao, Yan-song Wang, Ya-jiang Yuan, Zhang-hui Wan, Tian-chen Yao, Hai-hong Li, Pei-fu Tang, Xi-fan Mei   +7 more
doaj   +1 more source

Pharmacological mTOR inhibitors in ameliorating Alzheimer’s disease: current review and perspectives

Frontiers in Pharmacology
Traditionally, pharmacological mammalian/mechanistic targets of rapamycin (mTOR) kinase inhibitors have been used during transplantation and tumor treatment.
Pei-Lun Xie, Meng-Yu Zheng, Ran Han, Wei-Xin Chen, Jin-Hua Mao   +4 more
doaj   +1 more source

Rapamycin Exacerbates Staphylococcus aureus Pneumonia by Inhibiting mTOR-RPS6 in Macrophages

Journal of Inflammation Research, 2023
Fang-Yi Yu,* Kua Zheng,* Yin-Fang Wu,* Shen-Wei Gao, Qing-Yu Weng, Chen Zhu, Yan-Ping Wu, Miao Li, Zhong-Nan Qin, Jia-Fei Lou, Zhi-Hua Chen, Song-Min Ying, Hua-Hao Shen, Wen Li Key Laboratory of Respiratory Disease of Zhejiang Province ...
Yu FY, Zheng K, Wu YF, Gao SW, Weng QY, Zhu C, Wu YP, Li M, Qin ZN, Lou JF, Chen ZH, Ying SM, Shen HH, Li W   +13 more
doaj  

Glucose deprivation in tuberous sclerosis complex-related tumors

Cell & Bioscience, 2011
Background Cancer cells possess unique metabolic phenotypes that are determined by their underlying oncogenic pathways. Activation of the PI3K/Akt/mTOR signaling cascade promotes glycolysis and leads to glucose-dependence in tumors.
Jiang Xiuyun, Kenerson Heidi L, Yeung Raymond S   +2 more
doaj   +1 more source

Rapamycin Promotes the Expansion of Myeloid Cells by Increasing G-CSF Expression in Mesenchymal Stem Cells

Frontiers in Cell and Developmental Biology, 2022
Rapamycin, also known as sirolimus, an inhibitor of mammalian target of rapamycin (mTOR), is a regulatory kinase responsible for multiple signal transduction pathways.
Minghao Li, Minghao Li, Yanjie Lan, Juan Gao, Shengnan Yuan, Shuaibing Hou, Tengxiao Guo, Fei Zhao, Yuxia Wang, Weiping Yuan, Xiaomin Wang, Xiaomin Wang   +11 more
doaj   +1 more source

Total Synthesis of Rapamycin

Angewandte Chemie International Edition, 2007
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Maddess, M, Tackett, M, Watanabe, H, Brennan, P, Spilling, C, Scott, J, Osborn, D, Ley, S   +7 more
openaire   +3 more sources