Results 21 to 30 of about 257,231 (311)
Cells, 2022 Keratinocyte stem cells play a fundamental role in homeostasis and repair of stratified epithelial tissues. Transplantation of cultured keratinocytes autografts provides a landmark example of successful cellular therapies by restoring durable integrity ...
Giorgia Centonze +3 more
doaj +1 more source
Blood and skin-derived Sezary cells: differences in proliferation-index, activation of PI3K/AKT/mTORC1 pathway and its prognostic relevance [PDF]
, 2019 Sézary syndrome (SS) is a rare and aggressive variant of Cutaneous T-Cell Lymphoma characterized by neoplastic distribution mainly involving blood, skin, and lymph-node.
Benucci, Roberto +15 more
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The Journal of Reproduction and Development, 2022 Any abnormal activation of primordial follicles and subsequent depletion can irreversibly diminish the ovarian reserve, which is one of the major chemotherapy-induced adverse effects in young patients with cancer.
Xiuying CHEN +7 more
doaj +1 more source
Autophagy processes are dependent on EGF receptor signaling [PDF]
, 2018 Autophagy is a not well-understood conserved mechanism activated during nutritional deprivation in order to maintain cellular homeostasis. In the present study, we investigated the correlations between autophagy, apoptosis and the MAPK pathways in ...
Capodifoglio, Sabrina +12 more
core +1 more source
Prdx5 in the Regulation of Tuberous Sclerosis Complex Mutation-Induced Signaling Mechanisms
Cells, 2023 (1) Background: Tuberous sclerosis complex (TSC) mutations directly affect mTORC activity and, as a result, protein synthesis. In several cancer types, TSC mutation is part of the driver mutation panel.
Judit Bovari-Biri +3 more
doaj +1 more source
MTOR cross-talk in cancer and potential for combination therapy [PDF]
, 2018 The mammalian Target of Rapamycin (mTOR) pathway plays an essential role in sensing and integrating a variety of exogenous cues to regulate cellular growth and metabolism, in both physiological and pathological conditions.
Bazzichetto, C. +7 more
core +3 more sources
Search for Synergistic Drug Combinations to Treat Chronic Lymphocytic Leukemia
Cells, 2022 Finding synergistic drug combinations is an important area of cancer research. Here, we sought to rationally design synergistic drug combinations with an inhibitor of BTK kinase, ibrutinib, which is used for the treatment of several types of leukemia. We
Eleonora Ela Hezkiy +10 more
doaj +1 more source
Rapamycin attenuates acute seizure-induced astrocyte injury in mice in vivo [PDF]
, 2017 Astrocytes have been implicated in epileptogenesis and seizure-induced brain injury. Pathological studies reveal a variety of structural abnormalities in astrocytes, such as vacuolization and astrogliosis.
Guo, Dongjun, Wong, Michael, Zou, Jia
core +2 more sources
mTORC1-Mediated Angiogenesis is Required for the Development of Rosacea
Frontiers in Cell and Developmental Biology, 2021 Although multiple evidences suggest that angiogenesis is associated with the pathophysiology of rosacea, its role is still in debate. Here, we showed that angiogenesis was enhanced in skin lesions of both rosacea patients and LL37-induced rosacea-like ...
Qinqin Peng +33 more
doaj +1 more source
Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice [PDF]
, 2016 The FDA approved drug rapamycin increases lifespan in rodents and delays age-related dysfunction in rodents and humans. Nevertheless, important questions remain regarding the optimal dose, duration, and mechanisms of action in the context of healthy ...
Anderson +33 more
core +1 more source