Results 11 to 20 of about 8,083 (118)
Cells, 2021 Cardiac remodeling and contractile dysfunction are leading causes in hypertrophy-associated heart failure (HF), increasing with a population’s rising age.
Christiane Ott +10 more
doaj +1 more source
Biomedicines, 2021 Traumatic spinal cord injury (SCI) is untreatable and remains the leading cause of disability. Neuroprotection and recovery after SCI can be partially achieved by rapamycin (RAPA) treatment, an inhibitor of mTORC1, complex 1 of the mammalian target of ...
Ingrid Vargova +9 more
doaj +1 more source
Journal of the American Society of Nephrology, 2005 Progressive renal disease in the presence of proteinuria is characterized by an infiltration of inflammatory cells into the renal interstitium associated with incremental atrophy of tubular structures and replacement of the tubulointerstitium by fibrous scar.
openaire +4 more sources
T-regulatory cells in transplantology: from preparation to clinical applications
Бюллетень сибирской медицины, 2018 The intensive study of the cellular approaches for the correction of different pathologies, including immunopathological processes and oncology, as well as the investigation of the immunosuppressive role of the regulatory T-cells (Tregs) made conditions ...
S. N. Sennikov +2 more
doaj +1 more source
Cells, 2022 Keratinocyte stem cells play a fundamental role in homeostasis and repair of stratified epithelial tissues. Transplantation of cultured keratinocytes autografts provides a landmark example of successful cellular therapies by restoring durable integrity ...
Giorgia Centonze +3 more
doaj +1 more source
The Journal of Reproduction and Development, 2022 Any abnormal activation of primordial follicles and subsequent depletion can irreversibly diminish the ovarian reserve, which is one of the major chemotherapy-induced adverse effects in young patients with cancer.
Xiuying CHEN +7 more
doaj +1 more source
Prdx5 in the Regulation of Tuberous Sclerosis Complex Mutation-Induced Signaling Mechanisms
Cells, 2023 (1) Background: Tuberous sclerosis complex (TSC) mutations directly affect mTORC activity and, as a result, protein synthesis. In several cancer types, TSC mutation is part of the driver mutation panel.
Judit Bovari-Biri +3 more
doaj +1 more source
Search for Synergistic Drug Combinations to Treat Chronic Lymphocytic Leukemia
Cells, 2022 Finding synergistic drug combinations is an important area of cancer research. Here, we sought to rationally design synergistic drug combinations with an inhibitor of BTK kinase, ibrutinib, which is used for the treatment of several types of leukemia. We
Eleonora Ela Hezkiy +10 more
doaj +1 more source
, 2021 Inhibition of mTORC1 (mechanistic Target Of Rapamycin Complex 1) signaling promotes health and longevity in diverse model organisms. Over the past decade, excitement has built over the possibility that treatment with the mTORC1 inhibitor rapamycin can be utilized to treat or prevent age-related disease in humans. However, concerns over the side effects
openaire +2 more sources
mTORC1-Mediated Angiogenesis is Required for the Development of Rosacea
Frontiers in Cell and Developmental Biology, 2021 Although multiple evidences suggest that angiogenesis is associated with the pathophysiology of rosacea, its role is still in debate. Here, we showed that angiogenesis was enhanced in skin lesions of both rosacea patients and LL37-induced rosacea-like ...
Qinqin Peng +33 more
doaj +1 more source