Results 11 to 20 of about 164,975 (264)
Cells, 2021 Cardiac remodeling and contractile dysfunction are leading causes in hypertrophy-associated heart failure (HF), increasing with a population’s rising age.
Christiane Ott +10 more
doaj +1 more source
Biomedicines, 2021 Traumatic spinal cord injury (SCI) is untreatable and remains the leading cause of disability. Neuroprotection and recovery after SCI can be partially achieved by rapamycin (RAPA) treatment, an inhibitor of mTORC1, complex 1 of the mammalian target of ...
Ingrid Vargova +9 more
doaj +1 more source
TRPML1 agonist ML-SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux. [PDF]
FEBS Open BioTGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Yao J +10 more
europepmc +2 more sources
T-regulatory cells in transplantology: from preparation to clinical applications
Бюллетень сибирской медицины, 2018 The intensive study of the cellular approaches for the correction of different pathologies, including immunopathological processes and oncology, as well as the investigation of the immunosuppressive role of the regulatory T-cells (Tregs) made conditions ...
S. N. Sennikov +2 more
doaj +1 more source
Cells, 2022 Keratinocyte stem cells play a fundamental role in homeostasis and repair of stratified epithelial tissues. Transplantation of cultured keratinocytes autografts provides a landmark example of successful cellular therapies by restoring durable integrity ...
Giorgia Centonze +3 more
doaj +1 more source
The Journal of Reproduction and Development, 2022 Any abnormal activation of primordial follicles and subsequent depletion can irreversibly diminish the ovarian reserve, which is one of the major chemotherapy-induced adverse effects in young patients with cancer.
Xiuying CHEN +7 more
doaj +1 more source
Prdx5 in the Regulation of Tuberous Sclerosis Complex Mutation-Induced Signaling Mechanisms
Cells, 2023 (1) Background: Tuberous sclerosis complex (TSC) mutations directly affect mTORC activity and, as a result, protein synthesis. In several cancer types, TSC mutation is part of the driver mutation panel.
Judit Bovari-Biri +3 more
doaj +1 more source
Search for Synergistic Drug Combinations to Treat Chronic Lymphocytic Leukemia
Cells, 2022 Finding synergistic drug combinations is an important area of cancer research. Here, we sought to rationally design synergistic drug combinations with an inhibitor of BTK kinase, ibrutinib, which is used for the treatment of several types of leukemia. We
Eleonora Ela Hezkiy +10 more
doaj +1 more source
mTORC1-Mediated Angiogenesis is Required for the Development of Rosacea
Frontiers in Cell and Developmental Biology, 2021 Although multiple evidences suggest that angiogenesis is associated with the pathophysiology of rosacea, its role is still in debate. Here, we showed that angiogenesis was enhanced in skin lesions of both rosacea patients and LL37-induced rosacea-like ...
Qinqin Peng +33 more
doaj +1 more source
COVID 19 in a family with rare genetic disease of the nervous system
Неврология, нейропсихиатрия, психосоматика, 2022 We present familial tuberous sclerosis (TS) case complicated by COVID-19. COVID-19 aggravates the course of TS and may lead to a fatal outcome. We review the role of mTORC1 (mechanistic/mammalian Target of Rapamycin Complex 1) in the development and ...
M. Yu. Martynov +2 more
doaj +1 more source