Results 11 to 20 of about 257,231 (311)
Frontiers in Genetics, 2020 DNA methylation is an indispensable epigenetic modification that dynamically regulates gene expression and genome stability during cell growth and development processes.
Tingting Zhu +7 more
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The novel mTOR inhibitor RAD001 (Everolimus) induces antiproliferative effects in human pancreatic neuroendocrine tumor cells [PDF]
, 2007 Background/Aim: Tumors exhibiting constitutively activated PI(3) K/Akt/mTOR signaling are hypersensitive to mTOR inhibitors such as RAD001 (everolimus) which is presently being investigated in clinical phase II trials in various tumor entities, including
Albert JM +35 more
core +1 more source
Journal of the American Society of Nephrology, 2005 Progressive renal disease in the presence of proteinuria is characterized by an infiltration of inflammatory cells into the renal interstitium associated with incremental atrophy of tubular structures and replacement of the tubulointerstitium by fibrous scar.
openaire +4 more sources
Rapamycin: Drug Repurposing in SARS-CoV-2 Infection
Pharmaceuticals, 2021 Since December 2019, SARS-CoV-2 (COVID-19) has been a worldwide pandemic with enormous consequences for human health and the world economy. Remdesivir is the only drug in the world that has been approved for the treating of COVID-19.
Jiri Patocka +6 more
doaj +1 more source
Rapamycin-induced phosphaturia [PDF]
Nephrology Dialysis Transplantation, 2010 The mammalian target of rapamycin (mTOR) is known to stimulate a variety of transport mechanisms including the intestinal phosphate transporter NaPi-IIb. The present study was performed to elucidate whether mTOR similarly regulates the major renal tubular phosphate transporter NaPi-IIa.To this end, NaPi-IIa was expressed in Xenopus oocytes with or ...
Daniela S, Kempe +10 more
openaire +2 more sources
Cells, 2021 Cardiac remodeling and contractile dysfunction are leading causes in hypertrophy-associated heart failure (HF), increasing with a population’s rising age.
Christiane Ott +10 more
doaj +1 more source
Intranasal rapamycin ameliorates Alzheimer-like cognitive decline in a mouse model of Down syndrome [PDF]
, 2018 Background: Down syndrome (DS) individuals, by the age of 40s, are at increased risk to develop Alzheimer-like dementia, with deposition in brain of senile plaques and neurofibrillary tangles.
Arena, Andrea +9 more
core +3 more sources
Biomedicines, 2021 Traumatic spinal cord injury (SCI) is untreatable and remains the leading cause of disability. Neuroprotection and recovery after SCI can be partially achieved by rapamycin (RAPA) treatment, an inhibitor of mTORC1, complex 1 of the mammalian target of ...
Ingrid Vargova +9 more
doaj +1 more source
Comparative global immune-related gene profiling of somatic cells, human pluripotent stem cells and their derivatives: implication for human lymphocyte proliferation. [PDF]
, 2017 Human pluripotent stem cells (hPSCs), including embryonic stem cells (ESCs) and induced PSCs (iPSCs), represent potentially unlimited cell sources for clinical applications. Previous studies have suggested that hPSCs may benefit from immune privilege and
Allard, Patrick +12 more
core +1 more source
T-regulatory cells in transplantology: from preparation to clinical applications
Бюллетень сибирской медицины, 2018 The intensive study of the cellular approaches for the correction of different pathologies, including immunopathological processes and oncology, as well as the investigation of the immunosuppressive role of the regulatory T-cells (Tregs) made conditions ...
S. N. Sennikov +2 more
doaj +1 more source