Results 61 to 70 of about 2,535,115 (155)

Electrophysiological biomarkers in genetic movement disorders [PDF]

, 2008
BACKGROUND. Neurodegenerative diseases are diseases of the nervous system with progressive course leading to death. Treatment remains symptomatic. Development of neuroprotective agents has been hampered for various reasons. This includes the inability of
Schneider, K.S.A.I.M
core  

ATP1A3 mutation in the first asian case of rapid-onset dystonia-parkinsonism

, 2007
We report a 38-year-old Korean man with sporadic rapid-onset dystonia-parkinsonism (RDP), who had a Thr 618 Met mutation in the Na(+)/K(+)-ATPase alpha3 subunit gene (ATP1A3). At the age of 21, he acutely developed severe dystonia and parkinsonism, which
Kim, J. Y., Jeon, B. S., Lee, J. Y., Gollamudi, S., Ozelius, L. J.   +4 more
core   +1 more source

Acute and Chronic Local Field Potential Recordings in Dystonia—A Systematic Review

Movement Disorders Clinical Practice, EarlyView.
Abstract Dystonia is a hyperkinetic movement disorder increasingly conceptualized as a disorder of distributed network dysfunction involving the basal ganglia, cortex and cerebellum. Local field potentials (LFPs) recorded from deep brain stimulation (DBS) electrodes provide a unique opportunity to characterize the electrophysiological signatures ...
Jack Horan, Eoghan Donlon, Aoibheann Gill, Rosalyn Moran, Conor Fearon, Richard A. Walsh, Catherine Moran   +6 more
wiley   +1 more source

The influence of Na+,K+-ATPase on glutamate signaling in neurodegenerative diseases and senescence

Frontiers in Physiology, 2016
Decreased Na+,K+-ATPase (NKA) activity causes energy deficiency, which is commonly observed in neurodegenerative diseases. The NKA is constituted of three subunits: α, β and γ, with four distinct isoforms of the catalytic α subunit (α1-4).
Paula Fernanda Kinoshita, Jacqueline Alves Leite, Ana Maria Marques Orellana, Andrea Rodrigues Vasconcelos, Luis Eduardo M Quintas, Elisa Mitiko Kawamoto, Cristoforo eScavone   +6 more
doaj   +1 more source

A Gap Analysis of Deep Brain Stimulation for Childhood‐Onset Movement Disorders

Movement Disorders, EarlyView.
Abstract Background Deep brain stimulation (DBS) is an established and increasingly utilized therapy for childhood‐onset movement disorders. However, pediatric DBS poses unique challenges that are not adequately addressed by adult‐derived paradigms. Objective To identify key gaps in the current use of DBS in childhood‐onset movement disorders and to ...
Daniela Munoz‐Chesta, Carolina Gorodetsky, Todd M. Herrington, Angela L. Hewitt, Daniel E. Lumsden, Jennifer O'Malley, Terence Sanger   +6 more
wiley   +1 more source

The phenotypic spectrum of rapid-onset dystonia-parkinsonism (RDP) and mutations in the ATPIA3 gene

, 2007
Rapid-onset dystonia-parkinsonism (RDP) (also known as DYT12) is characterized by the abrupt onset of dystonia and parkinsonism and is caused by mutations in the ATP1A3 gene.
Riley, David, Tijssen, Marina A. J., Haake, Bret C., Muenchau, Alexander, Webb, David, Zaremba, Jacek, Aguiar, Patricia de Carvalho, Münchau, Alexander, Bressman, Susan B., Raymond, Deborah, Saunders-Pullman, Rachel, Frijns, C. J. M., Guimaraes, Joao, Dobyns, William B., Green, Andrew, Borg, Michel, Brashear, Allison, Klein, Christine, Gollamudi, Seema, Ozelius, Laurie J., de Carvalho Aguiar, Patricia, Linazasoro, Gurutz   +21 more
core   +1 more source

Driving Cerebellar Theta Oscillations Interferes With Voluntary Neck Movements in Cervical Dystonia

Movement Disorders, EarlyView.
Abstract Background Cervical dystonia (CD) is a movement disorder with a complex pathophysiology, including cerebellar abnormalities. Transcranial alternating current stimulation (tACS), a noninvasive neuromodulation technique capable of entraining brain oscillations, can transiently modulate neuronal activity and enhance resonant rhythms.
Davide Costa, Andrea Guerra, Daniele Birreci, Massimiliano Passaretti, Martina De Riggi, Anna Sofia Grandolfo, Valentina D'Onofrio, Luca Angelini, Giulia Paparella, Matteo Bologna   +9 more
wiley   +1 more source

Behavioural Characterization of a Novel Zebrafish Genetic Model of Rapid-onset Dystonia Parkinsonism [PDF]

, 2023
Rapid-onset dystonia parkinsonism (RDP) is a movement disorder that produces fixed postures and repetitive movements. RDP is caused by mutations in ATP1A3 which encodes a subunit of the neuronal Na+/K+ transporter that influences neuronal firing ...
Rahmanian, Shahrzad
core  

Delayed-onset drug-induced movement disorders

Psychiatry and Clinical Psychopharmacology, 2021
Delayed-onset drug-induced movement disorders (tardive syndromes) remain an important clinical problem. There are several phenomenologically and pharmacologically distinct types of tardive syndromes. The term tardive dyskinesia has been used to refer to
Oya Öztürk, Erhan Kurt, Timuçin Oral
doaj  

Kinematic Features of Voluntary and Involuntary Head Movements in Cervical Dystonia

Movement Disorders, EarlyView.
Abstract Background Cervical dystonia (CD) has a varied motor presentation, combining abnormal postures with complex involuntary head movements. Classification of these motor patterns remains imprecise, relying on descriptive terminology without robust definitions. Objectives To provide a kinematically‐grounded description of the motor phenomenology of
Thomas Hart, Davide Martino, Larissa R. Heideman, Martijn Beudel, Mark J. Edwards, Anna Sadnicka, Francesca Morgante   +6 more
wiley   +1 more source