Results 41 to 50 of about 32,523 (343)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Effects of ozone addition on the kinetics and efficiencies of methane conversion at fuel-rich conditions

open access: yesApplications in Energy and Combustion Science, 2023
Compression–expansion processes have the potential of converting mechanical work to chemical energy at fuel-rich conditions, allowing for the storage of fluctuating renewable energies.
Wenwen Xie   +3 more
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

open access: yesFEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour   +2 more
wiley   +1 more source

Effects of isoalcohol blending with gasoline on autoignition behavior in a rapid compression machine: Isopropanol and isobutanol

open access: yes, 2020
Alcohols, and particularly isoalcohols, are potentially advantageous blendstocks towards achieving efficient, low-carbon intensity internal combustion engines.
S. Goldsborough   +5 more
semanticscholar   +1 more source

Compact compressive arc and beam switchyard for energy recovery linac-driven ultraviolet free electron lasers

open access: yesPhysical Review Accelerators and Beams, 2017
High gain free electron lasers (FELs) driven by high repetition rate recirculating accelerators have received considerable attention in the scientific and industrial communities in recent years. Cost-performance optimization of such facilities encourages
J. A. G. Akkermans   +3 more
doaj   +1 more source

Using rapid compression machines for chemical kinetics studies [PDF]

open access: yesProgress in Energy and Combustion Science, 2014
Rapid compression machines (RCMs) are used to simulate a single compression stroke of an internal combustion engine without some of the complicated swirl bowl geometry, cycle-to-cycle variation, residual gas, and other complications associated with engine operating conditions.
Sung, Chih-Jen, Curran, Henry J.
openaire   +2 more sources

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

open access: yesFEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas   +6 more
wiley   +1 more source

Experimental and numerical investigation of the promoting effect of a cetane booster in a low-octane gasoline fuel in a rapid compression machine: A study of 2-ethylhexyl nitrate

open access: yesCombustion and Flame, 2020
Modern societies require cleaner and more efficient internal combustion engines. Low-temperature combustion (LTC) has been proved to be a good step toward this goal. This study aims at investigating the promoting effect of a cetane booster additive named
M. D. Le   +6 more
semanticscholar   +1 more source

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach   +23 more
wiley   +1 more source

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