Results 81 to 90 of about 503,144 (267)

Clinical diagnostic accuracy of the HIV rapid test ACCU-TELL anti-HIV 1 + 2 in sub-Saharan African region

BMC Infectious Diseases
Human Immunodeficiency Virus (HIV) is still a major health challenge. Around 1.5 million people are newly infected with HIV in the world every year. Screening and identification of HIV infected individuals is a major health challenge in the management of
Veronique M´pirah, Steeve Mbomo, Armel Mintsa, Amel Alame Emane, Ngondziga Ongala Djeff Chirack, Ndong Mebaley Telstar Ghestin, Quenard Edwina Lorine, Saidou Mahmoudou, Joel Fleury Djoba Siawaya, Paulin N. Essone   +9 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Malaria "diagnosis" and diagnostics in Afghanistan. [PDF]

, 2012
In many malaria-endemic areas, including Afghanistan, overdiagnosis of malaria is common. Even when using parasite-based diagnostic tests prior to treatment, clinicians commonly prescribe antimalarial treatment following negative test results.
Rowland, Mark, Wood, Molly, Kizito, James, Mayan, Ismail, Reynolds, Joanna, Mikhail, Amy, Ahmad, Tamanna, Motahed, Mohibullah, Anwari, Nadia, Karimullah, Karimullah, Baktash, Sayed Habib, Leslie, Toby, Chandler, Clare, Hazansai, Anwar   +13 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Computational Modelling of malaria diagnostic test [PDF]

, 2018
Early diagnosis of malaria is important for the prevention of malaria disease outbreak and providing an affected person with appropriate treatment early on.
Ryu, Kyungsuk, Fitzpatrick, Richard, Stefan, Melanie   +2 more
core   +1 more source

Evaluation of standard diagnostic rapid test kits for malaria diagnosis among HIV patients in Kano, Nigeria

African Journal of Laboratory Medicine, 2018
Background: Malaria diagnosis among HIV-positive patients is uncommon in Nigeria despite the high burden of both diseases. Objectives: We evaluated the performance of a malaria rapid diagnostic test (MRDT) against blood smear microscopy (BSM) among HIV ...
Henry A. Mbah, Feyisayo E. Jegede, Surajudeen A. Abdulrahman, Tinuade I. Oyeyi   +3 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Malaria Rapid Testing by Community Health Workers is Effective and Safe for Targeting Malaria Treatment: Randomised Cross-over Trial in Tanzania. [PDF]

, 2011
Early diagnosis and prompt, effective treatment of uncomplicated malaria is critical to prevent severe disease, death and malaria transmission. We assessed the impact of rapid malaria diagnostic tests (RDTs) by community health workers (CHWs) on ...
Petzold, M.G, Ka¨ llander, K., Max G. Petzold, Gustafsson, Lars L, Marian Warsame, Massele Amos, Källander, K,, Lars L Gustafsson, Gustafsson Lars L., Mubi, M., Massele, Amos, Max G Petzold, Premji, Z., Tomson, G, Björkman, Anders, Marycelina Mubi, Amos Massele, Premji, Zul, Ngasala Billy, Maganga, G., Karin Källander, Maganga, G,, Mubi, Marycelina, Anders Björkman, Warsame, M,, Warsame, M., Ngasala, Billy, Petzold Max G., Maganga, Gloria, Kallander, K., Björkman Anders, Zul Premji, Mårtensson, Andreas, Tomson, G., Martensson, A., Bjorkman, A., Ngasala, B., Mårtensson, A,, Petzold, Max G, Ngasala, B,, Göran Tomson, Tomson, Göran, Tomson Göran, Massele, A., Mårtensson Andreas, Lars L. Gustafsson, Massele, A,, Petzold, M.G., Bjo¨rkman, A., Janson, A,, Petzold, M.G,, Premji Zul, Maganga Gloria, Janson, A., Andreas Mårtensson, Gloria Maganga, Warsame, Marian, Gustafsson, L.L, Källander, Karin, Warsame Marian, Källander Karin, Mub, M., Janson Annika, Billy Ngasala, Janson, Annika, Mubi Marycelina, Gustafsson, L.L., Gustafsson, L.L,, Ma°rtensson, A., Annika Janson   +69 more
core   +1 more source

Utility of rapid diagnostic tests and microscopy to detect malaria in health facilities across the Solomon Islands

Malaria Journal
Background Accurate and efficient malaria diagnosis is critical for effective malaria control and elimination. Rapid diagnostic tests (RDTs) have been deployed over the last decade, particularly in rural and low-and-middle-income countries, as an ...
Genevieve Kerr, Lyndes Wini, John Leaburi, Joanne Macdonald, Tanya L. Russell   +4 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source