Results 71 to 80 of about 1,045,227 (267)

Seroepidemiology and molecular diversity of Leishmania donovani complex in Georgia [PDF]

, 2016
Background Leishmaniasis includes multiple clinical syndromes, most notably visceral, cutaneous, and mucosal forms. Visceral leishmaniasis (VL), also known as kala-azar, is a potentially fatal disease endemic to large parts of Africa and Asia, and in ...
Adeishvili, Ekaterine, Babuadze, Giorgi, Carrillo, Eugenia, Chakhunashvili, Giorgi, Chanturia, Gvantsa, De Koning, Harry P., Farlow, Jason, Imnadze, Paata, Kalandadze, Irine, Karseladze, Irakli, Kekelidze, Merab, Kokaia, Nora, Markhvashvili, Ivane, Murskvaladze, Mari, Sidamonidze, Ketevan, Tsereteli, David   +15 more
core   +3 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Clinical diagnostic accuracy of the HIV rapid test ACCU-TELL anti-HIV 1 + 2 in sub-Saharan African region

BMC Infectious Diseases
Human Immunodeficiency Virus (HIV) is still a major health challenge. Around 1.5 million people are newly infected with HIV in the world every year. Screening and identification of HIV infected individuals is a major health challenge in the management of
Veronique M´pirah, Steeve Mbomo, Armel Mintsa, Amel Alame Emane, Ngondziga Ongala Djeff Chirack, Ndong Mebaley Telstar Ghestin, Quenard Edwina Lorine, Saidou Mahmoudou, Joel Fleury Djoba Siawaya, Paulin N. Essone   +9 more
doaj   +1 more source

Multicenter Evaluation of the QIAstat-Dx Respiratory Panel for the Detection of Viruses and Bacteria in Nasopharyngeal Swab Specimens [PDF]

, 2020
The QIAstat-Dx Respiratory Panel (QIAstat-Dx RP) is a multiplex in vitro diagnostic test for the qualitative detection of 20 pathogens directly from nasopharyngeal swab (NPS) specimens. The assay is performed using a simple sample-to-answer platform with
Granato, Paul, Hannet, Irene, Hansen, Glen, Leber, Amy L., Lisby, Jan Gorm, Pareja, Josep, Relich, Ryan F., Schneider, Uffe Vest, Young, Stephen   +8 more
core   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Cost-effectiveness of malaria diagnosis using rapid diagnostic tests compared to microscopy or clinical symptoms alone in Afghanistan [PDF]

, 2015
Background Improving access to parasitological diagnosis of malaria is a central strategy for control and elimination of the disease. Malaria rapid diagnostic tests (RDTs) are relatively easy to perform and could be used in primary level clinics to ...
Anwar, Mohammed, Baktash, Sayed H., Drake, Thomas L., Grieve, Eleanor, Hansen, Kristian S., Leslie, Toby J., Mayan, Ismail, Mikhail, Amy, Mohammed, Nader, Rowland, Mark W., Whitty, Christopher J.M.   +10 more
core   +3 more sources

Cardiac biomarkers by point-of-care testing - back to the future? [PDF]

, 2020
The measurement of the cardiac troponins (cTn), cardiac troponin T (cTnT) and cardiac troponin I (cTnI) are integral to the management of patients with suspected acute coronary syndromes (ACS).
Collinson, P
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Evaluation of standard diagnostic rapid test kits for malaria diagnosis among HIV patients in Kano, Nigeria

African Journal of Laboratory Medicine, 2018
Background: Malaria diagnosis among HIV-positive patients is uncommon in Nigeria despite the high burden of both diseases. Objectives: We evaluated the performance of a malaria rapid diagnostic test (MRDT) against blood smear microscopy (BSM) among HIV ...
Henry A. Mbah, Feyisayo E. Jegede, Surajudeen A. Abdulrahman, Tinuade I. Oyeyi   +3 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source