Results 81 to 90 of about 7,879,048 (280)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Plant StressAS2/LOB transcription factors are crucial for plant organ development and stress responses, but their functions in fast-growing Phyllostachys edulis remain unclear.
Zhen Yu +7 more
doaj +1 more source
Organisational Factors of Rapid Growth of Slovenian Dynamic Enterprises
Organizacija, 2013 The authors provide key findings on the internal and external environmental factors of growth that affect the rapid growth of dynamic enterprises in relation to individual key organisational factors or functions. The key organisational relationships in a
Pšeničny Viljem, Novak Riko
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Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
A rapid, simple high capacity cholesterol crystal growth assay.
Journal of Lipid Research, 1995 Cholesterol crystal “nucleation time”, more recently referred to as cholesterol crystal observation time, is defined as the first appearance of cholesterol crystals from isotropic crystal-free biles on light microscopy.
P R Harvey, G A Upadhya
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Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Rapid growth of an orbital hemangiopericytoma with atypical histopathological findings
Clinical Ophthalmology, 2013 Luiz Frederico Pacheco,1,2 Bruno F Fernandes,1 Cristina Miyamoto,1,3 Shawn C Maloney,1 Bryan Arthurs,1 Miguel N Burnier Jr1,3 1Department of Ophthalmology, McGill University Health Center, Montreal, QC, Canada; 2Faculty of Medicine, Federal University of
Pacheco LF +5 more
doaj
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
The Chinese-born immigrant infant feeding and growth hypothesis
BMC Public Health, 2016 Background Rapid growth in the first six months of life is a well-established risk factor for childhood obesity, and child feeding practices (supplementation or substitution of breast milk with formula and early introduction of solids) have been reported
Kristy A. Bolton +4 more
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Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source