Results 71 to 80 of about 186,072 (301)

Maximizing Simulated Tropical Cyclone Intensity With Action Minimization

Journal of Advances in Modeling Earth Systems, 2019
Direct computer simulation of intense tropical cyclones (TCs) in weather models is limited by computational expense. Intense TCs are rare and have small‐scale structures, making it difficult to produce large ensembles of storms at high resolution ...
David A. Plotkin, Robert J. Webber, Morgan E O'Neill, Jonathan Weare, Dorian S. Abbot   +4 more
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

On the Realism of Tropical Cyclone Intensification in Global Storm‐Resolving Climate Models

Geophysical Research Letters
The physical processes governing a tropical cyclone's lifecycle are largely understood, but key processes occur at scales below those resolved by global climate models. Increased resolution may help simulate realistic tropical cyclone intensification. We
Alexander J. Baker, Benoît Vannière, Pier Luigi Vidale   +2 more
doaj   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Increasing lifetime maximum intensity of rapidly intensifying tropical cyclones over the western North Pacific

Environmental Research Letters, 2021
The long-term trend in the annual mean lifetime maximum intensity (LMI) of rapidly intensifying tropical cyclones (RI-TCs) over the western North Pacific (WNP) is investigated in this study.
Jinjie Song, Philip J Klotzbach, Yihong Duan   +2 more
doaj   +1 more source

The agroecological transition of agricultural systems in the Global South [PDF]

, 2018
Food security, jobs, ecological transition of agricultural production models and consumption patterns... Agroecology could be one of the solutions to meet the future challenges of humanity. Part of the United Nation's 17 Sustainable Development Goals, it
Côte, François-Xavier (ed.), Perret, Sylvain (ed.), Poirier-Magona, Emmanuelle (ed.), Rapidel, Bruno (ed.), Roudier, Philippe (ed.), Thirion, Marie-Cécile (ed.)   +5 more
core   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Rapid Intensification of Tropical Cyclones Observed by AMSU Satellites

Geophysical Research Letters, 2019
AbstractThis study examines the vertical structures of temperature and convection associated with rapid intensification of tropical cyclones using collocated Advanced Microwave Sounding Unit (AMSU) and HURSAT‐B1 satellite observations for 2003–2015.
Jialin Lin, Taotao Qian
openaire   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source