Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Solidification/stabilisation of soil contaminated with metal: a review [PDF]
, 2008 Solidification/stabilisation (S/S) is generically defined as a chemical and physical alteration technique of reducing the mobility as well as solubility of contaminants in wastes in order to convert them into chemically inert form.
Yin, C-Y, Goh, B.M.
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Microstructure and Mechanical Properties of Al-Si Alloys Produced by Rapid Solidification and Hot Extrusion. [PDF]
Materials (Basel), 2023 Noga P, Skrzekut T, Wędrychowicz M.
europepmc +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
A Novel Approach to Investigate the Superheating Grain Refinement Process of Aluminum-Bearing Magnesium Alloys Using Rapid Solidification Process. [PDF]
Materials (Basel), 2023 Jung S, Park Y, Lee Y.
europepmc +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Multiscale analysis of crystalline defect formation in rapid solidification of pure aluminium and aluminium-copper alloys. [PDF]
Philos Trans A Math Phys Eng Sci, 2022 Pinomaa T +8 more
europepmc +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Analysis of grain size and five-fold twins during rapid solidification processes inTi3Al alloy. [PDF]
RSC Adv, 2022 Li L, Gao T, Xie Q, Tian Z.
europepmc +1 more source