Results 71 to 80 of about 38,509 (306)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Procedure for Reconstruction, Modeling, and Fabrication Using Additive and Rapid Tooling Methods of a Training Model for Transsphenoidal Surgery

Journal of Manufacturing and Materials Processing
The endoscopic transsphenoidal approach (ETA) is a novel approach used by neurosurgeons and otolaryngologists to treat pituitary adenoma, and it has a long learning curve.
Giacomo Santona, Antonio Fiorentino, Francesco Doglietto, Mauro Serpelloni   +3 more
doaj   +1 more source

Micro injection molding of individualised implants using 3D printed molds manufactured via digital light processing

Current Directions in Biomedical Engineering, 2021
Here, we demonstrate a manufacturing process for individualised, small-sized implant prototypes. Our process is promising for the manufacturing of drug-releasing (micro)implants to be implanted in the round window niche (RWN-I, solid body, free-form ...
Mau Robert, Jüttner Gábor, Gao Ziwen, Matin Farnaz, Alcacer Labrador Dorian, Repp Felix, John Samuel, Scheper Verena, Lenarz Thomas, Seitz Hermann   +9 more
doaj   +1 more source

Pembuatan Cetakan Melalui Metode Rapid Tooling Pada Pembentukan Bola Plastik Dengan Proses Rotational Molding [PDF]

, 2015
Mold (cavity) yang selama ini digunakan dalam proses rotational molding terbatas hanya menggunakan bahan dari logam yang memerlukan waktu yang lama dan biaya yang besar.
, Bambang Waluyo Febriantoko, ST., MT, , Ir. Pramuko IP, MT., Budi, Setya   +2 more
core  

Form Accuracy Analysis of Cylindrical Parts Produced by Rapid Prototyping [PDF]

, 2007
Solid Freeform fabrication processes are being considered for creating fit and assembly nature functional parts. It is extremely important that these parts are within allowable dimensional and geometric tolerance.
Anjikar, Swapnil D., Gopal, A. Venu, Tagore, G.R.N.   +2 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Planning and control of a hybrid vacuum-forming system based on screw-pin tooling [PDF]

, 2010
This paper introduced planning and control of a hybrid vacuum-forming machine system (HAVES). The HAVES was developed to integrate CAD/CAM, screw-pin tooling, CNC, vacuum forming and optical measurement device together to produce vacuum forming ...
Gindy, Nabil, Wang, Yan, Wang, Zhijiang
core  

Variable cavity volume tooling for high-performance resin infusion moulding [PDF]

, 2010
This article describes the research carried out by Warwick under the BAE Systems/EPSRC programme ‘Flapless Aerial Vehicles Integrated Interdisciplinary Research – FLAVIIR’.
Achim V., Armstrong D. L., Chowdhury F. H., G J Gibbons, Gibbons G. J., Grande J., J J Segui-Garza, McConnell V. P., R G Hansell, Schwartz M. M., Sutton G., Toi Y.   +11 more
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Performance Analysis of Enhanced 3D Printed Polymer Molds for Metal Injection Molding Process

Metals, 2018
Conventionally, molds for metal injection molding (MIM) process are fabricated using metallic materials using conventional machining processes. Machined metal molds are resilient and therefore could be suitable for mass production of MIM parts.
Khurram Altaf, Junaid A. Qayyum, A. Majdi A. Rani, Faiz Ahmad, Puteri S. M. Megat-Yusoff, Masri Baharom, A. Rashid A. Aziz, Mirza Jahanzaib, Randall M. German   +8 more
doaj   +1 more source