Results 91 to 100 of about 38,509 (306)
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Analysis of the Geometric Accuracy of Wax Models Produced Using PolyJet Molds
Tehnički GlasnikThe article presents an analysis of the geometric accuracy of wax models produced using PolyJet molds. Photopolymer resin was used to make the molds, and the surface of the model was finished in a gloss mode in the 3D printing process. This allows you to
Mariusz Cygnar +6 more
doaj +1 more source
Journal of Manufacturing and Materials Processing, 2020 While deep drawing of sheet metals is economical at high volumes, it can be very costly for manufacturing prototypes, mainly due to high tooling costs.
Georg Bergweiler +3 more
doaj +1 more source
Rapid manufacturing as a tool for agile manufacturing: applications and implementation perspectives [PDF]
, 2006 Manufacturing engineers and technologists around the globe are already well familiar with manufacturing methodologies and systems developments in the last part of the twentieth century.
Bateman, RJ, Cheng, K
core
Controlling the Microstructure of Arc Sprayed Shells [PDF]
, 1991 Techniques for controlling the microstructure of sprayed steel structures are discussed in this paper. Steel is arc sprayed onto shaped substrates to form tooling.
Fussell, P.S. +3 more
core +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Modeling of acetosolv pulping of oil palm fronds using response surface methodology and wavelet neural networks [PDF]
, 2019 Mathematical models based on response surface methodology (RSM) and wavelet neural networks (WNNs) in conjunction with a central composite design were developed in order to study the influence of pulping variables viz. acetic acid, temperature, time, and
Ibrahim, Mazlan +4 more
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source