Results 91 to 100 of about 1,789,575 (241)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Computer simulation of thermoforming process and its verification using a rapid tooling mould

MATEC Web of Conferences, 2018
The results of computer simulation of thermoforming process made using ANSYS Polyflow software are presented in this paper. The analysis of the wall thickness distribution across an U-shaped thermoformed product manufactured using a positive mould was ...
Modławski Michał, Jaruga Tomasz
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Fabrication of Graphene Nanoparticle Reinforced Feedstock Filaments for Sustainable Rapid Tooling and Green Manufacturing

Journal of Nanotechnology
The growing demand for sustainable rapid tooling in 3D printing highlights the requirement for such advanced materials that are designed using the framework of green chemistry principles.
Suraj Ghising, Rashi Tyagi, Vinay Kumar, Nitesh Kumar, Amit Verma, Daniel Amoako Darko   +5 more
doaj   +1 more source

Polymer Tools Produced by Fused Filament Fabrication for Steel-Bending Process: Effect of Layering Orientation

Journal of Manufacturing and Materials Processing
Rapid tooling with polymer tools produced via additive manufacturing offers significant benefits in sheet metal forming processes as it allows for the production of parts with high accuracy while reducing tool production costs.
Luca Giorleo, Kudret Irem Deniz
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Utilização das tecnologias de estereolitografia e microfusão para aplicações em prototipagem rápida e ferramental rápido [PDF]

, 2001
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico.Recentemente, diversas tecnologias de prototipagem rápida têm surgido para reduzir os tempos inerentes às re-iterações e ajustes necessários para criar um produto de alta
Grellmann, Dauri Alberto
core  

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

High-Tech Solutions and Concepts - Hochtechnologielösungen und anwendbare Praxis-Konzepte. Euro-u Rapid 2006

, 2022
Der 7. Internationale Anwender-Event der Fraunhofer-Allianz Rapid Prototyping zum Rapid Prototyping, Rapid Tooling und Rapid Manufacturing präsentiert am 27. und 28. November 2006 in Frankfurt/Main aktuelle Rapid-Fortschritte.

core   +1 more source