Results 71 to 80 of about 5,131,582 (279)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Determination of Rare Earth Elements in Barite-associated Rare Earth Ores by Alkaline Precipitation Separation-Inductively Coupled Plasma-Mass Spectrometry

Yankuang ceshi, 2019
BACKGROUND When inductively coupled plasma-mass spectrometry (ICP-MS) is used to determine the rare earth elements (REE) in the barite-associated light rare earth ores, Ba and light rare earth elements La, Ce, Pr, Nd, Sm, cause severe mass spectral ...
DONG Xue-lin, HE Hai-yang, CHU Qin, QIU Xiu-mei, TANG Xing-min   +4 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Rare earth elements in nuclear medicine [PDF]

Саратовский научно-медицинский журнал, 2014
The review focuses on the key applications of stable and radioactive isotopes of rare earth elements in the technology of nuclear medicine, radionuclide diagnostics and therapy, as well as magnetic resonance imaging and binary radiotherapy technologies.
Kodina G.E., Kulakov V.N., Sheino I.N.
doaj  

The Content and Distribution Characteristics of Heavy Metals in Root Soils in the Jiajika Lithium Resource Area, Western Sichuan Province

Yankuang ceshi, 2019
BACKGROUND When inductively coupled plasma-mass spectrometry (ICP-MS) is used to determine the rare earth elements (REE) in the barite-associated light rare earth ores, Ba and light rare earth elements La, Ce, Pr, Nd, Sm, cause severe mass spectral ...
GAO Juan-qin, YU Yang, WANG Deng-hong, LIU Li-jun, WANG Wei, HAO Xue-feng, DAI Hong-zhang   +6 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Geopolitics and rare earth metals

, 2022
Rare earth elements are critical in the production of consumer products, renewables, and green, industrial, and defense products. Using more than thirty years of Japanese import data, we document statistically significant relationships between ...
Omura, Akihiro, Fan, John Hua, John Hua Fan, Eduardo Roca, Akihiro Omura, Roca, Eduardo   +5 more
core   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Magnetism in crystalline rare-earth compounds [PDF]

, 2011
In this thesis we investigate the magnetism of a selection of crystalline mate- rials that display fascinating macroscopic properties, largely due to the complex behaviour of rare-earth ions. The technique of choice is diffraction; shown to pro- vide the
Johnson, Roger Douglas, JOHNSON, ROGER,DOUGLAS   +1 more
core