Results 181 to 190 of about 1,159 (247)
High‐Fat Diet Exacerbates Neuropathology in a Transgenic Mouse Model of Multiple System Atrophy
Movement Disorders, EarlyView.Abstract Background Multiple system atrophy (MSA) is a rare and devastating neurodegenerative disorder. Accumulating clinical and preclinical evidence suggests that diabetes and insulin resistance may adversely influence MSA pathophysiology. Objective We investigated the potential association between diabetes, impaired glucose homeostasis, and MSA ...
Marie‐Laure Arotcarena +7 more
wiley +1 more source
Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future
Medicinal Research Reviews, EarlyView.ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley +1 more source
Review of Congenital Myasthenic Syndrome Caused by Pathogenic Variants in GFPT1
Muscle &Nerve, EarlyView.ABSTRACT Glutamine:fructose‐6‐phosphate transaminase 1 (GFPT1) catalyzes the first and rate‐limiting step of the hexosamine biosynthetic pathway (HBP) to generate UDP‐GlcNAc. GFPT1 exon 9 is specifically spliced in in striated muscles, which makes a long isoform of GFPT1 (GFPT1‐L).
Kinji Ohno +5 more
wiley +1 more source
Treatment Preferences of Patients With Myasthenia Gravis: A Qualitative Study
Muscle &Nerve, EarlyView.ABSTRACT Introduction/Aims The burden of myasthenia gravis (MG) is often underestimated, and studies usually focus on the symptom burden. However, treatment‐related adverse events also contribute to patients' burdens and affect their treatment decisions.
Meg Mendoza +6 more
wiley +1 more source
Review of nutrition management of pediatric intestinal pseudo‐obstruction
Nutrition in Clinical Practice, EarlyView.Abstract Chronic intestinal pseudo‐obstruction (CIPO) is a rare, heterogeneous, and debilitating disorder characterized by profound intestinal dysmotility and severe nutrition challenges. Its presentation resembles that of mechanical bowel obstruction, but CIPO occurs in the absence of luminal obstruction.
Senthilkumar Sankararaman +5 more
wiley +1 more source
Warfare, Labor, and Urban Stress: Divergent Health Trajectories in Mongol‐Period Karakorum
International Journal of Osteoarchaeology, EarlyView.ABSTRACT This study examines major palaeopathological trends in Mongol‐period Karakorum and incorporates them into the existing body of research in order to deepen our understanding of health and survival, the impacts of conflict and violence on past populations, and the lived experiences of the city's diverse inhabitants within the broader socio ...
Júlia Olive‐Busom +4 more
wiley +1 more source
Rare Sugar Production through Isomerization of Reducing Sugars in Subcritical Fluids
Japan Journal of Food EngineeringTakashi KOBAYASHI +4 more
openaire +1 more source
Fruit use and fruit processing by euphonias, specialized avian frugivores
Oikos, EarlyView.Euphonias (Neotropical passerines in the genera Euphonia and Chlorophonia) form the quintessential example of a specialized avian frugivore, combining a high reliance on fruit as food and the restriction of fruit taxa exploited. To understand their specialization, we explored the integration of fruit morphological and nutritional traits with their ...
Marco A. Pizo +3 more
wiley +1 more source
Oikos, EarlyView.Seed dispersal by frugivores is a central process linking plant reproduction, animal foraging, population persistence, and ecosystem resilience. Currently, the spatial template sustaining these interactions is rapidly reconfigured by habitat loss and fragmentation promoted by human activity.
Eliana Cazetta, Paulo R. Guimarães Jr
wiley +1 more source
Pediatric Anesthesia, EarlyView.ABSTRACT Introduction Pediatric ambulatory surgery has become the dominant model of surgical care in the United States, driven primarily by economic forces. There is variability in regional practice patterns, quality improvement cycles, and outcomes. Opportunity exists to overcome knowledge gaps and provide sustainable pathways of quality improvement ...
Jennifer L. Chiem +6 more
wiley +1 more source