Results 101 to 110 of about 232,899 (308)
FEBS Open Bio, EarlyView.Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar +4 more
wiley +1 more source
Post-translational modification of RAS proteins. [PDF]
Curr Opin Struct Biol, 2021 Campbell SL, Philips MR.
europepmc +1 more source
Biological production of CLA and investigation of anticarcinogenic activity [PDF]
, 2003 This study investigated a potential mechanism of action underlying the anticancer activity of conjugated lmoleic acid (CLA), referring to a mixture of positional and geometric conjugated isomers of lmoleic acid Ras, an oncogene necessary for normal cell ...
McGrath, Emma
core
Ras proteins increase Ca2+-responsiveness of smooth muscle contraction
, 1993 G-proteins may be involved in receptor-mediated Ca2+-sensitization of smooth muscle contraction, but the responsible G-proteins are not yet known. Here we show that in β-escin skinned mesenteric microarteries, H-ras p21 proteins, preactivated with GTP or
Pfitzer, G. +5 more
core +1 more source
Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids
FEBS Open Bio, EarlyView.Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão +3 more
wiley +1 more source
Local renin angiotensin system in the reproductive system: a review of literature
Frontiers in Endocrinology, 2013 The renin–angiotensin system (RAS) is well known as regulator of electrolytes and blood pressure. Besides this function, there are numerous studies supporting the idea of a local tissue RAS.
Daniel eHerr +2 more
doaj +1 more source
Impaired Proteolysis of Noncanonical RAS Proteins Drives Clonal Hematopoietic Transformation. [PDF]
Cancer Discov, 2022 Chen S +26 more
europepmc +1 more source
Differential modification of Ras proteins by ubiquitination
, 2006 Ras proteins are essential components of signal transduction pathways that control cell proliferation, differentiation, and survival. It is well recognized that the functional versatility of Ras proteins is accomplished through their differential ...
Sobczyk, A. +3 more
core +1 more source
Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells
FEBS Open Bio, EarlyView.Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim +4 more
wiley +1 more source
Classical RAS proteins are not essential for paradoxical ERK activation induced by RAF inhibitors. [PDF]
Proc Natl Acad Sci U S A, 2022 Lai LP +8 more
europepmc +1 more source