Advanced Functional Materials, EarlyView.MagPiezo enables wireless activation of endogenous Piezo1 channels without genetic modification using 19 nm magnetic nanoparticles and low‐intensity magnetic fields. It generates torque forces at the piconewton scale to trigger mechanotransduction in endothelial cells, standing as a novel platform to interrogate and manipulate Piezo1 activity in vitro.
Susel Del Sol‐Fernández +7 more
wiley +1 more source
NRAS is unique among RAS proteins in requiring ICMT for trafficking to the plasma membrane. [PDF]
Life Sci Alliance, 2021 Ahearn IM +4 more
europepmc +1 more source
Advanced Healthcare Materials, EarlyView.Few‐layered three dimansional conductive graphene foams are promising cytocompatible platforms to transdifferentiate mesenchymal stem cells into Schwann cell‐like phenotypes using electrical and microstructural cues. Applied electrical stimulation conditions resulted in activation of MAPK, neurotrphin and RAS signaling pathways that led to upregulation
Ekin G. Simsar +9 more
wiley +1 more source
A protein kinase C‐independent pathway leading to c‐Jun‐dependent expression of 100‐kDa Ras GTPase‐activating protein in JEG‐3 human choriocarcinoma cells [PDF]
, 2000 Fei Ye +3 more
openalex +1 more source
Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy
Advanced Materials, EarlyView.Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa +3 more
wiley +1 more source
Crystal structure of NRAS Q61K with a ligand-induced pocket near switch II
European Journal of Cell BiologyThe RAS isoforms (KRAS, HRAS and NRAS) have distinct cancer type-specific profiles. NRAS mutations are the second most prevalent RAS mutations in skin and hematological malignancies.
Teklab Gebregiworgis +5 more
doaj +1 more source
Sequence-Selective Covalent CaaX-Box Receptors Prevent Farnesylation of Oncogenic Ras Proteins and Impact MAPK/PI3 K Signaling. [PDF]
ChemMedChem, 2021 Franz M +10 more
europepmc +1 more source
Evidence for a Ras-dependent extracellular signal-regulated protein kinase (ERK) cascade. [PDF]
, 1992 David J. Robbins +5 more
openalex +1 more source
Mesoporous Silica Nanoparticles in Biomedicine: Advances and Prospects
Advanced Materials, EarlyView.Mesoporous silica nanoparticles offer unique properties like high surface area, tunable pores, and functionalization. They excel in drug delivery, tissue engineering, and stimuli‐responsive therapies, enabling targeted and controlled treatments. With roles in cancer therapy and diagnostics, their clinical translation requires addressing challenges in ...
Miguel Manzano, María Vallet‐Regí
wiley +1 more source
Targeting the RAS pathway by mitogen-activated protein kinase inhibitors [PDF]
, 2015 Michael K. Kießling, Gerhard Rogler
openalex +1 more source