Results 151 to 160 of about 370,587 (208)
Some of the next articles are maybe not open access.
Seminars in Immunology, 2000
Ras proteins were identified through their association with cell transformation. Since then they have been shown to regulate cell growth, differentiation and apoptosis, as well as influencing processes such as cell migration and neuronal activity. Ras regulates a number of signalling molecules by translocating them to the plasma membrane for activation.
M F, Olson, R, Marais
openaire +2 more sources
Ras proteins were identified through their association with cell transformation. Since then they have been shown to regulate cell growth, differentiation and apoptosis, as well as influencing processes such as cell migration and neuronal activity. Ras regulates a number of signalling molecules by translocating them to the plasma membrane for activation.
M F, Olson, R, Marais
openaire +2 more sources
Current Opinion in Cell Biology, 1993
A combination of genetic and biochemical techniques has revealed key players in the Ras signal transduction pathway that link receptors to growth and differentiation. Rho and Rac have been shown to couple extracellular signals to the organization of the actin cytoskeleton, while ADP ribosylation factor is required for the formation of non-clathrin ...
openaire +2 more sources
A combination of genetic and biochemical techniques has revealed key players in the Ras signal transduction pathway that link receptors to growth and differentiation. Rho and Rac have been shown to couple extracellular signals to the organization of the actin cytoskeleton, while ADP ribosylation factor is required for the formation of non-clathrin ...
openaire +2 more sources
Isoprenoids Influence Expression of Ras and Ras-Related Proteins
Biochemistry, 2002Mevalonate depletion by inhibition of hydroxymethylglutaryl coenzyme A reductase impairs post-translational processing of Ras and Ras-related proteins. We have previously shown that this mevalonate depletion also leads to the upregulation of Ras, Rap1a, RhoA, and RhoB.
Sarah A, Holstein +2 more
openaire +2 more sources
Biochimie, 1988
Several recent discoveries indicate that the ras genes, frequently activated to a transforming potential in some human tumours, belong to a large family that can be divided into three main branches: the first branch represented by the ras, ral and rap genes; the second branch, by the rho genes; and the third branch, by the rab genes. The C-terminal end
openaire +2 more sources
Several recent discoveries indicate that the ras genes, frequently activated to a transforming potential in some human tumours, belong to a large family that can be divided into three main branches: the first branch represented by the ras, ral and rap genes; the second branch, by the rho genes; and the third branch, by the rab genes. The C-terminal end
openaire +2 more sources
Peptide inhibitors targeting Ras and Ras-associated protein–protein interactions
European Journal of Medicinal ChemistryPeptides represent attractive molecules for targeting protein-protein interactions, and peptide drug development has made great progress during the last decades. Ras protein, the most promising target in cancer therapy, is one of the major growth drivers in various cancers.
Dan Han +5 more
openaire +2 more sources
Prenylation of ras and ras-Related Proteins
1991In common with certain other cellular proteins, a CAAX motif (C=cysteine, A=Aliphatic, X=any amino acid) is found at the C-terminus of all ras proteins. This motif undergoes a triplet of closely coupled post-translational modifications. First, a prenoid derivative is linked as a thioether to the cysteine residue (Hancock et al,1989; Casey et al,1989 ...
J. F. Hancock +8 more
openaire +1 more source
Science, 1989
In the Table of Contents of the 24 March 1989 issue, the title of the report "Histamine is an intracellular messenger mediating platelet aggregation" by S. P. Saxena et al. appearing on page 1596 was incorrectly printed.
L, Tong +3 more
openaire +2 more sources
In the Table of Contents of the 24 March 1989 issue, the title of the report "Histamine is an intracellular messenger mediating platelet aggregation" by S. P. Saxena et al. appearing on page 1596 was incorrectly printed.
L, Tong +3 more
openaire +2 more sources
Ras proteins as therapeutic targets
Biochemical Society Transactions, 2018Oncogenic mutations in RAS genes underlie the pathogenesis of many human tumours, and there has been intense effort for over 30 years to develop effective and tolerated targeted therapeutics for patients with Ras-driven cancers. This review summarises the progress made in Ras drug discovery, highlighting some of the recent developments in directly ...
Atanu, Chakraborty +2 more
openaire +2 more sources