Advanced Materials Interfaces, EarlyView.Hybrid piezoelectric scaffolds offer a promising route for Central Nervous System regeneration by combining structural and electrical cues to support neural stem cell growth. This review highlights their potential to overcome current challenges in neural tissue engineering by exploring porous hybrid materials, their biological interactions, and ...
Heather F. Titterton +2 more
wiley +1 more source
The effects of mutant Ras proteins on the cell signalome. [PDF]
Cancer Metastasis Rev, 2020 Takács T +5 more
europepmc +1 more source
A Phase 2 Randomized Placebo-Controlled Adjuvant Trial of GI-4000, a Recombinant Yeast Expressing Mutated RAS Proteins in Patients with Resected Pancreas Cancer. [PDF]
J Pancreat Cancer, 2021 Muscarella P +15 more
europepmc +1 more source
Cell migration directionality and speed are independently regulated by RasG and Gβ in Dictyostelium cells in electrotaxis. [PDF]
, 2019 Motile cells manifest increased migration speed and directionality in gradients of stimuli, including chemoattractants, electrical potential and substratum stiffness.
Devreotes, Peter N +6 more
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Mechanobiological Dynamics‐Inspired Mechanomodulatory Biomaterials
Advanced Science, EarlyView.Recent advances in biomaterial‐mediated mechanomodulation of stem cell fate, encompassing 2, 3, and 4D systems and their synergy with artificial intelligence is overviewed. By integrating knowledge from diverse fields, this review ultimately aims to inspire the design of smarter biomaterial systems that can accelerate the clinical translation of ...
Letao Yang +6 more
wiley +1 more source
Advanced Science, EarlyView.This study successfully establishes adamantinomatous craniopharyngioma (ACP) patient‐derived organoids (PDOs) that preserve the histopathological and genetic features of the original tumors. Through drug sensitivity assays and subsequent mechanistic analyses, the study demonstrates that Ceritinib exerts its inhibitory effects on ACP PDO growth by ...
Huarong Zhang +15 more
wiley +1 more source
Small molecule inhibitors of RAS proteins with oncogenic mutations. [PDF]
Cancer Metastasis Rev, 2020 Orgován Z, Keserű GM.
europepmc +1 more source
Focal Adhesion Kinase Overexpression Enhances Ras-dependent Integrin Signaling to ERK2/Mitogen-activated Protein Kinase through Interactions with and Activation of c-Src [PDF]
, 1997 David D. Schlaepfer, Tony Hunter
openalex +1 more source
Binding of Vav to Grb2 through dimerization of Src homology 3 domains [PDF]
, 1994 The protooncogenic protein Vav has the structure of an intracellular signal transducer. It is exclusively expressed in cells of hematopoietic lineage and plays a crucial role in hematopoietic cell differentiation.
Baltimore, David, Ye, Zheng-Sheng
core
Advanced Science, EarlyView.CCDC41 is essential for meiotic maturation in mouse oocytes through regulating Rab7‐positive endosomes fusion with lysosomes and Rab11a‐positive vesicle fusion with the plasma membrane. Abstract Coiled‐coil domain‐containing protein 41 (CCDC41), a core component of centriolar distal appendages involved in centriole assembly and ciliary vesicle docking,
Ying Tian +12 more
wiley +1 more source