Results 161 to 170 of about 370,587 (208)
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Ras-GTPase Activating Protein (GAP): A Putative Effector for Ras
Cellular Signalling, 1997One attractive candidate for a Ras effector protein, other than the Raf kinases, is Ras-GAP. Indeed, recent literature suggests that besides the Raf/MAP kinase cascade, additional pathways must be stimulated to elicit a full biological response to Ras. Ras binds the COOH terminal domain of Ras-GAP, while the NH2 terminal domain appears to be essential ...
B, Tocque +5 more
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The Ras Superfamily G-Proteins
2013The Ras superfamily G-proteins are monomeric proteins of approximately 21kDa that act as a molecular switch to regulate a variety of cellular processes. The structure of the Ras superfamily G-proteins, their regulators as well as posttranslational modification of these proteins leading to their membrane association have been elucidated.
Ashley L, Tetlow, Fuyuhiko, Tamanoi
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Activation of Ras Proteins by Ras Guanine Nucleotide Releasing Protein Family Members
2006Ras guanine nucleotide releasing proteins (RasGRPs) function as guanine nucleotide exchange factors for Ras proteins. Thus, RasGRPs are direct activators of Ras proteins and contribute an important role in various cell-signaling pathways that are regulated by the activation state of Ras proteins.
Que T, Lambert, Gary W, Reuther
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Targeting Oncogenic RAS Protein
New England Journal of Medicine, 2022Dan L, Longo, Neal, Rosen
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2006
The Ras branch of the Ras superfamily of GTPases comprises 20 proteins that can be classified in 7 subgroups (Ras, Rap, Ral, R-Ras, Rit/Rin, Rheb, ARRHI/Di-Ras) according to sequence homology. Most of them act as molecular switches that alternate between an inactive GDP-bound and an active GTP-bound conformation, except for ARHI/Di-Ras that remain ...
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The Ras branch of the Ras superfamily of GTPases comprises 20 proteins that can be classified in 7 subgroups (Ras, Rap, Ral, R-Ras, Rit/Rin, Rheb, ARRHI/Di-Ras) according to sequence homology. Most of them act as molecular switches that alternate between an inactive GDP-bound and an active GTP-bound conformation, except for ARHI/Di-Ras that remain ...
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Rethinking Ras: p21 Ras Proteins and Cardiac Signal Transduction
1995Hypertrophy of cardiac muscle occurs both as the normal mode of ventricular growth after birth and, as a pathophysiological response, in adaptation to mechanical overload [1–3]. Classically, cardiac myocytes lose their proliferative capacity shortly after birth, and subsequent enlargement is due to an increase in cell size, mediated in turn by an ...
Maha Abdellatif, Michael D. Schneider
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Three-dimensional structure of Ras and Ras-related proteins
1995Abstract The structures of several different wild-type and mutantp21 complexes have been determined by two groups. A listof the published structures is shown in Table 1 togetherwith the resolutions obtained in the crystallographic analyses.For wild-type and one oncogenic mutant both thetriphosphate and diphosphate structures have been ...
Alfred Wittinghofer, Alfonso Valencia
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Ras proteins and theras-related signal transduction pathway
Radiation and Environmental Biophysics, 1991Mammalian ras genes may naturally acquire oncogenic transformation potential through some point mutations which result in the impairment of the normal ras protein functions, and which are localised in codons 12, 13 or 61. Mutationally activated ras alleles were found in a wide variety of human and carcinogen (including radiation)-induced animal ...
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Integrative oncology: Addressing the global challenges of cancer prevention and treatment
Ca-A Cancer Journal for Clinicians, 2022Jun J Mao,, Msce +2 more
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