Results 201 to 210 of about 228,557 (259)
Some of the next articles are maybe not open access.
Seminars in Immunology, 2000
Ras proteins were identified through their association with cell transformation. Since then they have been shown to regulate cell growth, differentiation and apoptosis, as well as influencing processes such as cell migration and neuronal activity. Ras regulates a number of signalling molecules by translocating them to the plasma membrane for activation.
Richard Marais, Michael F. Olson
exaly +3 more sources
Ras proteins were identified through their association with cell transformation. Since then they have been shown to regulate cell growth, differentiation and apoptosis, as well as influencing processes such as cell migration and neuronal activity. Ras regulates a number of signalling molecules by translocating them to the plasma membrane for activation.
Richard Marais, Michael F. Olson
exaly +3 more sources
Biochimie, 1988
Several recent discoveries indicate that the ras genes, frequently activated to a transforming potential in some human tumours, belong to a large family that can be divided into three main branches: the first branch represented by the ras, ral and rap genes; the second branch, by the rho genes; and the third branch, by the rab genes. The C-terminal end
openaire +2 more sources
Several recent discoveries indicate that the ras genes, frequently activated to a transforming potential in some human tumours, belong to a large family that can be divided into three main branches: the first branch represented by the ras, ral and rap genes; the second branch, by the rho genes; and the third branch, by the rab genes. The C-terminal end
openaire +2 more sources
Isoprenoids Influence Expression of Ras and Ras-Related Proteins
Biochemistry, 2002Mevalonate depletion by inhibition of hydroxymethylglutaryl coenzyme A reductase impairs post-translational processing of Ras and Ras-related proteins. We have previously shown that this mevalonate depletion also leads to the upregulation of Ras, Rap1a, RhoA, and RhoB.
Sarah A, Holstein +2 more
openaire +2 more sources
Ras-GTPase Activating Protein (GAP): A Putative Effector for Ras
Cellular Signalling, 1997One attractive candidate for a Ras effector protein, other than the Raf kinases, is Ras-GAP. Indeed, recent literature suggests that besides the Raf/MAP kinase cascade, additional pathways must be stimulated to elicit a full biological response to Ras. Ras binds the COOH terminal domain of Ras-GAP, while the NH2 terminal domain appears to be essential ...
Bruno Tocque +2 more
exaly +3 more sources
Current Opinion in Cell Biology, 1993
A combination of genetic and biochemical techniques has revealed key players in the Ras signal transduction pathway that link receptors to growth and differentiation. Rho and Rac have been shown to couple extracellular signals to the organization of the actin cytoskeleton, while ADP ribosylation factor is required for the formation of non-clathrin ...
openaire +2 more sources
A combination of genetic and biochemical techniques has revealed key players in the Ras signal transduction pathway that link receptors to growth and differentiation. Rho and Rac have been shown to couple extracellular signals to the organization of the actin cytoskeleton, while ADP ribosylation factor is required for the formation of non-clathrin ...
openaire +2 more sources
Prenylation of ras and ras-Related Proteins
1991In common with certain other cellular proteins, a CAAX motif (C=cysteine, A=Aliphatic, X=any amino acid) is found at the C-terminus of all ras proteins. This motif undergoes a triplet of closely coupled post-translational modifications. First, a prenoid derivative is linked as a thioether to the cysteine residue (Hancock et al,1989; Casey et al,1989 ...
J. F. Hancock +8 more
openaire +1 more source