Results 191 to 200 of about 228,557 (259)

Dual Effects of β‐TrCP2 Deletion in Bone Homeostasis: Suppression of Osteoclastogenesis and Enhancement of Osteoblast Activity

Arthritis &Rheumatology, Accepted Article.
Objectives To elucidate role of beta‐transducin repeat‐containing protein 2 (β‐TrCP2) in bone homeostasis for its potential as a therapeutic target for osteoporosis. Methods The role of β‐TrCP2 in bone phenotypes was investigated using systemic β‐TrCP1KO and β‐TrCP2KO mice, along with myeloid‐specific conditional β‐TrCP2KO (β‐TrCP2ΔM) mice.
Woo Jung Kim, Sora Han, Hye In Ka, Sun Young Lee, Jiwon Kim, Hyunjeong Joo, Sujung Soh, Gaeun Oh, Kyung Hyun Yoo, Seung Hyun Han, Yeongkag Kwon, Choogon Lee, Kyung‐Hyun Park‐Min, Se Hwan Mun, Young Yang   +14 more
wiley   +1 more source

Dynamic genetic and nongenetic RAS-pathway activation drives resistance to FLT3 and BCL2 inhibitor therapy. [PDF]

Blood
Kennedy VE, Peretz CAC, Walia A, Chyla B, Sun Y, Hill J, Tran E, Koh AD, Ferng T, Pintar S, Jones MF, Popescu B, Lomeli I, Chehab F, Murad N, John A, Roy R, Olshen A, Berryhill CA, Davis C, Angus SP, Rivera JM, Meshulam A, Stieglitz E, Joshi S, Traer E, Dail M, Hamidi H, Altman JK, Daver N, Levis M, McCloskey J, Perl AE, Smith CC.   +33 more
europepmc   +1 more source

The association between systemic inflammation as measured by calprotectin and autoantibody load in rheumatoid arthritis

Arthritis &Rheumatology, Accepted Article.
Background Plasma calprotectin is a marker of neutrophil activity. Its relation to the clinical phenotype and autoantibodies in rheumatoid arthritis (RA) is only partly understood. We therefore aimed to investigate the association between calprotectin and clinical parameters, CRP, ESR, anti‐CCP2 and other anti‐modified protein autoantibodies (AMPAs) in
Caroline Grönwall, Linda Mathsson Alm, Helga Westerlind, Isabel Gehring, Nasim Ghasemzadeh, Niels Steen Krogh, Siri Lillegraven, Espen Haavardsholm, Martina Johannesson, Tore K. Kvien, Johan Rönnelid, Tue Wenzel Kragstrup, Bente Glintborg, Merete Lund Hetland, Hilde Berner Hammer, The Danish Rheumatologic Biobank Study Group, Swedish Rheumatology Quality Register Biobank Study Group(SRQb), Johan Askling, Oliver Hendricks, Estrid Høgdall, Dorte Vendelbo Jensen, Heidi Lausten Munk, Jens Kristian Pedersen, Torkell Ellingsen, Anne Gitte Loft, Ellen‐Margrethe Hauge, Salome Kristensen, Lene Dreyer, Asta Linauskas, Søren Jacobsen, Carl Turesson, Solbritt Rantapää Dahlqvist, Lena Björkman, Alf Kastbom, Eva Baecklund   +34 more
wiley   +1 more source

The Allosteric Revolution: From Static Structures to Conformational Ensembles and Next-Generation Therapeutics. [PDF]

J Mol Biol
Nussinov R, Jang H.
europepmc   +1 more source

Outcomes of Tapering Biologic and Targeted Synthetic DMARDs in Rheumatoid Arthritis: A Multicenter Randomized Non‐Inferiority Trial

Arthritis &Rheumatology, Accepted Article.
Objective Evidence supporting tapering of biologic or targeted synthetic disease‐modifying antirheumatic drugs (b/tsDMARDs) in rheumatoid arthritis (RA) patients with sustained low disease activity (LDA) remains limited. We evaluated the efficacy and safety of a structured b/tsDMARD tapering strategy in patients with RA who had achieved sustained LDA ...
Dong‐Jin Park, Sung‐Eun Choi, Ji‐Hyoun Kang, Jung‐Yoon Choe, Hye‐Soon Lee, So‐Young Bang, Yun‐Hong Cheon, Sang‐Il Lee, Mingyo Kim, Yoon‐Kyoung Sung, Soo‐Kyung Cho, Jae Hyun Jung, Sung Hae Chang, Sung Won Lee, Yeon‐Ah Lee, Seung‐Geun Lee, Hyun‐Sook Kim, Seung‐Ki Kwok, Seung‐Cheol Shim, Shin‐Seok Lee   +19 more
wiley   +1 more source

Functional characterization of the 9q34.13 locus identifies RAPGEF1 as a candidate gene modulating risk for melanoma and nevi via RAS activation. [PDF]

Am J Hum Genet
Thakur R, Xu M, Thornock AM, Yon J, Anyaso-Samuel S, Lauss M, Rehling T, Bui-Raborn L, Sowards H, Duncan G, Jessop L, Myers T, Chari R, Long E, Funderburk K, Yin J, Hennessey R, Hsieh E, Levin H, Machiela MJ, Zhang T, Jönsson G, Bishop DT, Newton-Bishop J, Nsengimana J, Iles MM, Landi MT, Law MH, Andresson T, Choi J, Zon LI, Shi J, Melanoma Meta-Analysis Consortium, Brown KM.   +33 more
europepmc   +1 more source

GDP-Loaded K-Ras Transiently Binds to Effector B-Raf RBD, Mirroring the Structure of the Active GTP-Loaded Complex. [PDF]

J Am Chem Soc
Xiang X, Basnet M, Yuan C, Bruschweiler-Li L, Brüschweiler R.   +4 more
europepmc   +1 more source

KRAS in Colorectal Cancer: Tumorigenesis, Surgical Implications and Evolving Treatment Target. [PDF]

Curr Oncol
Iftikhar S, Xiao AH, Jin Z, Aly EH.
europepmc   +1 more source

Genome-wide identification and functional characterization of <i>LBD</i> transcription factors uncover their stress adaptation mechanisms in tobacco and eggplant. [PDF]

Front Plant Sci
Wu T, Zhang B, Guo Q, Li Y, Li C, He Q, Chen D, Gu G, Chen A, Yang Z, Li W, Xie X.   +11 more
europepmc   +1 more source

Thermal Stability, Plasma Pharmacokinetics, and Tumor Response Modeling of a Cell-Penetrating Protein That Cleaves RAS Family GTPases. [PDF]

ACS Pharmacol Transl Sci
Sugawara T, Nomura TK, Honda R.
europepmc   +1 more source