Results 211 to 220 of about 228,557 (259)

Stimulation of angiogenesis by Ras proteins

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2004
Cells that have acquired a proliferative advantage form islets of hyperplasia during the initial stages of tumor development. Like normal cells, they require oxygen and nutrients to survive and proliferate. The centre of the islets is characterized by low oxygen pressure and low pH, conditions that stimulate the sprouting of new capillaries from nearby
Onno, Kranenburg, Martijn F B G, Gebbink, Emile E, Voest   +2 more
openaire   +2 more sources

Structure of ras Proteins

Science, 1989
In the Table of Contents of the 24 March 1989 issue, the title of the report "Histamine is an intracellular messenger mediating platelet aggregation" by S. P. Saxena et al. appearing on page 1596 was incorrectly printed.
L, Tong, M V, Milburn, A M, de Vos, S H, Kim   +3 more
openaire   +2 more sources

Ras proteins as therapeutic targets

Biochemical Society Transactions, 2018
Oncogenic mutations in RAS genes underlie the pathogenesis of many human tumours, and there has been intense effort for over 30 years to develop effective and tolerated targeted therapeutics for patients with Ras-driven cancers. This review summarises the progress made in Ras drug discovery, highlighting some of the recent developments in directly ...
Atanu, Chakraborty, Emily, Linnane, Sarah, Ross   +2 more
openaire   +2 more sources

Peptide inhibitors targeting Ras and Ras-associated protein–protein interactions

European Journal of Medicinal Chemistry
Peptides represent attractive molecules for targeting protein-protein interactions, and peptide drug development has made great progress during the last decades. Ras protein, the most promising target in cancer therapy, is one of the major growth drivers in various cancers.
Dan Han, Anpeng Li, Lie Zhu, Chunlin Zhuang, Qingjie Zhao, Yan Zou   +5 more
openaire   +2 more sources

The Ras Superfamily G-Proteins

2013
The Ras superfamily G-proteins are monomeric proteins of approximately 21kDa that act as a molecular switch to regulate a variety of cellular processes. The structure of the Ras superfamily G-proteins, their regulators as well as posttranslational modification of these proteins leading to their membrane association have been elucidated.
Ashley L, Tetlow, Fuyuhiko, Tamanoi
openaire   +2 more sources

The very druggable RAS proteins

Trends in Cancer
RAS genes encode molecular switches that control cell growth and survival, and their oncogenic mutations drive many cancers. Once deemed 'undruggable', RAS is now being challenged by innovative inhibitors. Recent advances, reported by Stanland and Huggins et al.
Marie C. Hasselluhn, Kenneth P. Olive
openaire   +2 more sources

Activation of Ras Proteins by Ras Guanine Nucleotide Releasing Protein Family Members

2006
Ras guanine nucleotide releasing proteins (RasGRPs) function as guanine nucleotide exchange factors for Ras proteins. Thus, RasGRPs are direct activators of Ras proteins and contribute an important role in various cell-signaling pathways that are regulated by the activation state of Ras proteins.
Que T, Lambert, Gary W, Reuther
openaire   +2 more sources

Three-dimensional structure of Ras and Ras-related proteins

1995
Abstract The structures of several different wild-type and mutantp21 complexes have been determined by two groups. A listof the published structures is shown in Table 1 togetherwith the resolutions obtained in the crystallographic analyses.For wild-type and one oncogenic mutant both thetriphosphate and diphosphate structures have been
Alfred Wittinghofer, Alfonso Valencia
openaire   +1 more source

The ras Oncogene Protein

1989
To date, over 40 discrete genes (oncogenes and proto-oncogenes) have been shown capable of inducing cellular transformation and tumor development (Bishop 1987). Only a few of these oncogenes have actually been shown to have a significant role in human cancer.
M. S. Marshall, M. D. Schaber, U. S. Vogel, W. S. Hill, A. S. Ng, E. M. Scolnick, R. A. F. Dixon, I. S. Sigal, J. B. Gibbs   +8 more
openaire   +1 more source

Targeting Oncogenic RAS Protein

New England Journal of Medicine, 2022
Dan L, Longo, Neal, Rosen
openaire   +2 more sources