Results 221 to 230 of about 232,899 (308)

PI3K Regulates Wild-type RAS Signaling to Confer Resistance to KRAS Inhibition. [PDF]

Cancer Res
Ge X, Singh J, Li W, Markham CS, Ruiz CF, Stites EC, Bhattacharyya M, Liu Y, Muzumdar MD.   +8 more
europepmc   +1 more source

Solvation Structure and Dynamics of the Thiocyanate Anion in mixed N,N‐Dimethylformamide‐Water Solvents: A Molecular Dynamics Approach

ChemPhysChem, Volume 26, Issue 6, March 15, 2025.
The solvation structure and dynamics of the SCN− anion in mixed N, N‐Dimethylformamide (DMF)‐water liquid solvents is investigated using classical molecular dynamics simulations. A preferential solvation of SCN− by the water molecules is observed in the first hydration shell, followed by a second shell consisting by both DMF and water molecules.
Ioannis Skarmoutsos, Ilias G. Karvounis
wiley   +1 more source

RAS protein subfamily

, 2018
Jeremy Jones, Hamish Smith
openaire   +1 more source

Targeting the Ras-Ral Signaling Axis in Type 2 Diabetes Mellitus: A Dual-Modulation Approach to Correcting Insulin Resistance and β-Cell Dysfunction. [PDF]

Pharmaceuticals (Basel)
Thulasi N, Harithpriya K, Ganesan K, Ramkumar KM.   +3 more
europepmc   +1 more source

Intravenous Lipopolysaccharide Challenge in Healthy Participants Reveals Pharmacodynamic Markers in Blood and Bone Marrow for Early‐Phase Oncology Drug Development

Clinical Pharmacology &Therapeutics, EarlyView.
Demonstrating pharmacological effects in early‐phase oncology clinical trials remains challenging, largely due to the lack of robust pharmacodynamic markers. Lipopolysaccharide (LPS) is used as an immune challenge agent in healthy participants to study drugs for autoimmune conditions.
Igor Radanović, Ingrid Tomljanović, Wieke H. Grievink, Diana R. Pereira, Michelle Osse, Peter van Balen, Maria J. Juachon, Marieke L. de Kam, Lisa Pagan, Manon A.A. Jansen, Matthijs Moerland, Jacobus J. Bosch   +11 more
wiley   +1 more source

Regulation and Implementation of Apoptosis in Melanoma Tumor Cells with <i>BRAF</i>, <i>NRAS</i>, and <i>NF1</i> Gene Mutations. [PDF]

Curr Issues Mol Biol
Nosareva OL, Pomytkina EA, Korotkova ON, Tumanova AV, Stepovaya EA, Nagaitsev VM, Kochurina EA, Bakina OV, Kokorev OV, Spirina LV.   +9 more
europepmc   +1 more source

The role of Rho GTPases in facial morphogenesis

Developmental Dynamics, EarlyView.
The role of small GTPases, RHOA, RAC1, and CDC42 and pathway mediators is reviewed in the context of embryonic facial development. Lip fusion requires cytoskeletal remodeling during morphogenesis of the facial processes and during lip fusion. Fnm, frontonasal mass; lnp, lateral nasal process; mnp, medial nasal process; mxp, maxillary process; np, nasal
Isra Ibrahim, Joy M. Richman
wiley   +1 more source

Use of tandem-affinity chromatography to incorporate nucleotide loading of small GTPases during their purification. [PDF]

Protein Sci
Oladimeji R, Odo C, Lewis E, Reid G, Johnson CW.   +4 more
europepmc   +1 more source

Loss of Twist1 leads to disruption of ciliary length, endocytic vesicle dynamics, and cell–cell junctions during neural tube formation

Developmental Dynamics, EarlyView.
Abstract Background Endocytosis constitutes a fundamental cellular process governing development through coordinated regulation of plasma membrane remodeling and ciliogenesis, processes essential for cell shape changes and tissue development. Although Twist1 null embryos display complete cranial neural tube (NT) closure defects and conditional knockout
Derrick Thomas, Brittany M. Hufft‐Martinez, Zarna Lalwani, Vi Pham, Mary Elmeniawi, An J. Tran, Jianming Xu, Irfan Saadi, Walid D. Fakhouri   +8 more
wiley   +1 more source

Membrane Curvature and Cancer: Mechanisms, Implications, and Therapeutic Perspectives. [PDF]

Cancers (Basel)
Damalas A, Kyriazis ID, Tutkus M, Angelidis C, Trachana V.   +4 more
europepmc   +1 more source