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RAS Proteins and Their Regulators in Human Disease [PDF]
Cell, 2017 RAS proteins are binary switches, cycling between ON and OFF states during signal transduction. These switches are normally tightly controlled, but in RAS-related diseases, such as cancer, RASopathies, and many psychiatric disorders, mutations in ...
Dhirendra K Simanshu +2 more
exaly +4 more sources
Membrane Fusion and SNAREs: Interaction with Ras Proteins [PDF]
International Journal of Molecular Sciences, 2022 Azzurra Margiotta
exaly +2 more sources
Small molecule inhibitors of RAS proteins with oncogenic mutations [PDF]
Cancer and Metastasis Reviews, 2020 Zoltan Orgovan +2 more
exaly +2 more sources
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Seminars in Immunology, 2000
Ras proteins were identified through their association with cell transformation. Since then they have been shown to regulate cell growth, differentiation and apoptosis, as well as influencing processes such as cell migration and neuronal activity. Ras regulates a number of signalling molecules by translocating them to the plasma membrane for activation.
M F, Olson, R, Marais
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Ras proteins were identified through their association with cell transformation. Since then they have been shown to regulate cell growth, differentiation and apoptosis, as well as influencing processes such as cell migration and neuronal activity. Ras regulates a number of signalling molecules by translocating them to the plasma membrane for activation.
M F, Olson, R, Marais
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Isoprenoids Influence Expression of Ras and Ras-Related Proteins
Biochemistry, 2002Mevalonate depletion by inhibition of hydroxymethylglutaryl coenzyme A reductase impairs post-translational processing of Ras and Ras-related proteins. We have previously shown that this mevalonate depletion also leads to the upregulation of Ras, Rap1a, RhoA, and RhoB.
Sarah A, Holstein +2 more
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Current Opinion in Cell Biology, 1993
A combination of genetic and biochemical techniques has revealed key players in the Ras signal transduction pathway that link receptors to growth and differentiation. Rho and Rac have been shown to couple extracellular signals to the organization of the actin cytoskeleton, while ADP ribosylation factor is required for the formation of non-clathrin ...
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A combination of genetic and biochemical techniques has revealed key players in the Ras signal transduction pathway that link receptors to growth and differentiation. Rho and Rac have been shown to couple extracellular signals to the organization of the actin cytoskeleton, while ADP ribosylation factor is required for the formation of non-clathrin ...
openaire +2 more sources
Stimulation of angiogenesis by Ras proteins
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2004Cells that have acquired a proliferative advantage form islets of hyperplasia during the initial stages of tumor development. Like normal cells, they require oxygen and nutrients to survive and proliferate. The centre of the islets is characterized by low oxygen pressure and low pH, conditions that stimulate the sprouting of new capillaries from nearby
Onno, Kranenburg +2 more
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Biochimie, 1988
Several recent discoveries indicate that the ras genes, frequently activated to a transforming potential in some human tumours, belong to a large family that can be divided into three main branches: the first branch represented by the ras, ral and rap genes; the second branch, by the rho genes; and the third branch, by the rab genes. The C-terminal end
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Several recent discoveries indicate that the ras genes, frequently activated to a transforming potential in some human tumours, belong to a large family that can be divided into three main branches: the first branch represented by the ras, ral and rap genes; the second branch, by the rho genes; and the third branch, by the rab genes. The C-terminal end
openaire +2 more sources