Results 251 to 260 of about 372,429 (303)

Isoprenoids Influence Expression of Ras and Ras-Related Proteins

Biochemistry, 2002
Mevalonate depletion by inhibition of hydroxymethylglutaryl coenzyme A reductase impairs post-translational processing of Ras and Ras-related proteins. We have previously shown that this mevalonate depletion also leads to the upregulation of Ras, Rap1a, RhoA, and RhoB.
Sarah A, Holstein, Christine L, Wohlford-Lenane, Raymond J, Hohl   +2 more
openaire   +2 more sources

The ras superfamily proteins

Biochimie, 1988
Several recent discoveries indicate that the ras genes, frequently activated to a transforming potential in some human tumours, belong to a large family that can be divided into three main branches: the first branch represented by the ras, ral and rap genes; the second branch, by the rho genes; and the third branch, by the rab genes. The C-terminal end
openaire   +2 more sources

Peptide inhibitors targeting Ras and Ras-associated protein–protein interactions

European Journal of Medicinal Chemistry
Peptides represent attractive molecules for targeting protein-protein interactions, and peptide drug development has made great progress during the last decades. Ras protein, the most promising target in cancer therapy, is one of the major growth drivers in various cancers.
Dan Han, Anpeng Li, Lie Zhu, Chunlin Zhuang, Qingjie Zhao, Yan Zou   +5 more
openaire   +2 more sources

Prenylation of ras and ras-Related Proteins

1991
In common with certain other cellular proteins, a CAAX motif (C=cysteine, A=Aliphatic, X=any amino acid) is found at the C-terminus of all ras proteins. This motif undergoes a triplet of closely coupled post-translational modifications. First, a prenoid derivative is linked as a thioether to the cysteine residue (Hancock et al,1989; Casey et al,1989 ...
J. F. Hancock, K. Cadwallader, A. I. Magee, C. Newman, T. Giannakouros, E. Fawell, J. Armstrong, H. F. Paterson, C. J. Marshall   +8 more
openaire   +1 more source

Structure of ras Proteins

Science, 1989
In the Table of Contents of the 24 March 1989 issue, the title of the report "Histamine is an intracellular messenger mediating platelet aggregation" by S. P. Saxena et al. appearing on page 1596 was incorrectly printed.
L, Tong, M V, Milburn, A M, de Vos, S H, Kim   +3 more
openaire   +2 more sources

Ras proteins as therapeutic targets

Biochemical Society Transactions, 2018
Oncogenic mutations in RAS genes underlie the pathogenesis of many human tumours, and there has been intense effort for over 30 years to develop effective and tolerated targeted therapeutics for patients with Ras-driven cancers. This review summarises the progress made in Ras drug discovery, highlighting some of the recent developments in directly ...
Atanu, Chakraborty, Emily, Linnane, Sarah, Ross   +2 more
openaire   +2 more sources

Ras-GTPase Activating Protein (GAP): A Putative Effector for Ras

Cellular Signalling, 1997
One attractive candidate for a Ras effector protein, other than the Raf kinases, is Ras-GAP. Indeed, recent literature suggests that besides the Raf/MAP kinase cascade, additional pathways must be stimulated to elicit a full biological response to Ras. Ras binds the COOH terminal domain of Ras-GAP, while the NH2 terminal domain appears to be essential ...
B, Tocque, I, Delumeau, F, Parker, F, Maurier, M C, Multon, F, Schweighoffer   +5 more
openaire   +2 more sources

The Ras Superfamily G-Proteins

2013
The Ras superfamily G-proteins are monomeric proteins of approximately 21kDa that act as a molecular switch to regulate a variety of cellular processes. The structure of the Ras superfamily G-proteins, their regulators as well as posttranslational modification of these proteins leading to their membrane association have been elucidated.
Ashley L, Tetlow, Fuyuhiko, Tamanoi
openaire   +2 more sources

Activation of Ras Proteins by Ras Guanine Nucleotide Releasing Protein Family Members

2006
Ras guanine nucleotide releasing proteins (RasGRPs) function as guanine nucleotide exchange factors for Ras proteins. Thus, RasGRPs are direct activators of Ras proteins and contribute an important role in various cell-signaling pathways that are regulated by the activation state of Ras proteins.
Que T, Lambert, Gary W, Reuther
openaire   +2 more sources

Targeting Oncogenic RAS Protein

New England Journal of Medicine, 2022
Dan L, Longo, Neal, Rosen
openaire   +2 more sources