Results 271 to 280 of about 232,899 (308)

An expanding role for RAS GTPase activating proteins (RAS GAPs) in cancer

Advances in Biological Regulation, 2014
The RAS pathway is one of the most commonly deregulated pathways in human cancer. Mutations in RAS genes occur in nearly 30% of all human tumors. However in some tumor types RAS mutations are conspicuously absent or rare, despite the fact that RAS and downstream effector pathways are hyperactivated.
Ophélia, Maertens, Karen, Cichowski
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The ras Oncogene Protein

1989
To date, over 40 discrete genes (oncogenes and proto-oncogenes) have been shown capable of inducing cellular transformation and tumor development (Bishop 1987). Only a few of these oncogenes have actually been shown to have a significant role in human cancer.
M. S. Marshall, M. D. Schaber, U. S. Vogel, W. S. Hill, A. S. Ng, E. M. Scolnick, R. A. F. Dixon, I. S. Sigal, J. B. Gibbs   +8 more
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Targeting Oncogenic RAS Protein

New England Journal of Medicine, 2022
Dan L, Longo, Neal, Rosen
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Ras proteins and theras-related signal transduction pathway

Radiation and Environmental Biophysics, 1991
Mammalian ras genes may naturally acquire oncogenic transformation potential through some point mutations which result in the impairment of the normal ras protein functions, and which are localised in codons 12, 13 or 61. Mutationally activated ras alleles were found in a wide variety of human and carcinogen (including radiation)-induced animal ...
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[RAS proteins and related proteins].

Comptes rendus des seances de la Societe de biologie et de ses filiales, 1995
Since the mid-eighties, numerous small G-proteins of the ras gene superfamily have been identified and characterized; more than sixty members are distributed into four subfamilies: ras, rho, rab and ran. Although it appears that, structurally, the products of the ras superfamily are related and implicated in various and diverse intracellular mechanisms:
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Ras Family Proteins

2006
The Ras branch of the Ras superfamily of GTPases comprises 20 proteins that can be classified in 7 subgroups (Ras, Rap, Ral, R-Ras, Rit/Rin, Rheb, ARRHI/Di-Ras) according to sequence homology. Most of them act as molecular switches that alternate between an inactive GDP-bound and an active GTP-bound conformation, except for ARHI/Di-Ras that remain ...
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The ras protein is not associated with exocytosis

Nature, 1987
V, Adam-Vizi, D, Knight, A, Hall
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Ras Protein

RCSB Protein Data Bank, 2012
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Ras-Related Protein R-Ras

2020
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Ras Proteins☆

2016
S.D. George, C.J. Der
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