Results 241 to 250 of about 232,899 (308)

The small molecule simufilam dose‐dependently attenuates the worsening of seizures in a mouse model of tuberous sclerosis complex

Epilepsia, EarlyView.
Abstract Objective Novel epilepsy treatments for patients with tuberous sclerosis complex (TSC) and focal cortical dysplasia type II (FCDII) are urgently needed. In these patients, mutations in the mechanistic target of rapamycin (mTOR) pathway genes lead to mTOR hyperactivity and focal cortical malformations that frequently cause intractable epilepsy ...
Branden Stansley, Md. Monirul Islam, Dean J. Aguiar, Zoë Fuchs, Mackenzie Catron, Stephen Morairty, Ying Yuan, Radleigh Santos, Jingguo Hou, Annelies de Kater, George B. Thornton, Angelique Bordey   +11 more
wiley   +1 more source

Spliceosome induction is a druggable dependency of RAS-driven senescence and cancer. [PDF]

Nat Commun
Wagner V, Bousset L, Ascensão-Ferreira M, Sun B, Barragan Avila JE, Kaizeler A, Martins-Silva R, Rahbari M, Fernández-Vaquero M, Haston S, Tinti M, Pombo J, Khadayate S, Roth S, Schürch CM, Martínez-Barbera JP, Bahat A, Wee KB, Morton JP, Malek N, Innes AJ, Vernia S, Barbosa-Morais NL, Gallage S, Heikenwalder M, Gil J.   +25 more
europepmc   +1 more source

Lipid‐based Nano‐delivery systems as a promising strategy for the treatment of epilepsy: Current status and challenges

Epilepsia Open, EarlyView.
Abstract Objective Epilepsy is a prevalent chronic neurological disorder characterized by abnormal neuronal electrical activity. The primary treatment modality for individuals with epilepsy (PWE) is antiseizure medication (ASM). The multiple potential factors contributing to treatment resistance in epilepsy may be attributed to the inability of ASMs to
Priya Kannan Varshini, Arunachalam Divya, Kumar Sowndharya, Parthiban Jeevitha, Selvam Manoj, Ashiq Rahman, Athil Ahamed, Ravichandiran Abirahul, Paranthaman Subash, Sulekha Khute   +9 more
wiley   +1 more source

IQGAP3, the overlooked oncogenic twin of IQGAP1: mapping its interactome and functional roles across cellular signaling and cancer. [PDF]

Cell Commun Signal
Basu S, Dixit M.
europepmc   +1 more source

Inconsistent Transcriptomic Responses to Hexabromocyclododecane in Japanese Quail: A Comparative Analysis of Results From Four Different Study Designs

Environmental Toxicology and Chemistry, EarlyView.
Abstract Efforts to use transcriptomics for toxicity testing have classically relied on the assumption that chemicals consistently produce characteristic transcriptomic signatures that are reflective of their mechanism of action. However, the degree to which transcriptomic responses are conserved across different test methodologies has seldom been ...
Paul Béziers, Elena Legrand, Emily Boulanger, Niladri Basu, Jessica D. Ewald, Paula Henry, Markus Hecker, Jianguo Xia, Natalie Karouna‐Renier, Doug Crump, Jessica Head   +10 more
wiley   +1 more source

The dual axis of tumorigenesis: MAPK and PI3K/AKT pathways in papillary thyroid carcinoma. [PDF]

Oncoscience
Rathod G, Parmar P.
europepmc   +1 more source

Jaceosidin inhibits cell viability and induces apoptosis in non-small cell lung cancer by inhibiting the Ras/Raf/MEK/ERK and Akt pathways. [PDF]

Oncol Lett
Cao X, Ma C, Wang X, Wang C, Shen L, Wei J, Yang R, Li Y, He X, Chen L.   +9 more
europepmc   +1 more source

Heterotrimeric G Protein-RasGAP Coupling Drives Adaptation During Chemotaxis. [PDF]

Cells
Xu X, Kim RD, Hyun H, Shukla RD, Jin T.
europepmc   +1 more source

Targeting ICMT: A promising strategy in cancer treatment (Review). [PDF]

Oncol Lett
Hu J, Xiao Y, Tang J.
europepmc   +1 more source

Protein lipidation in cardiovascular homeostasis, development, and disease. [PDF]

Clin Sci (Lond)
Cully D, Harrison S, Sadovsky M, Miner GE, Edwards W.   +4 more
europepmc   +1 more source