Results 291 to 300 of about 380,814 (333)

Activity of direct KRAS(G12C) inhibitors in preclinical models of pediatric cancer. [PDF]

Mol Cancer Ther
Price HE, Stauffer S, Lee H, Isanogle KA, Wu Y, Powell K, Baker A, Stauffer L, Perciaccante AJ, Jewell CP, Hernandez ER, Aljabri AK, Odeniyide P, Pratilas CA, Burgan W, Edmondson EF, Difilippantonio S, Kortum RL, Shern JF, Jenkins LM, Rossman KL, Yohe ME.   +21 more
europepmc   +1 more source

Dietary Flavonoids as Cross-System Modulators of Hypertension and Intestinal Permeability. [PDF]

Molecules
Danh JP, Gewirtz AT, Feresin RG.
europepmc   +1 more source

Analysis of Patients With Monocytic and Monocytic‐Like Acute Myeloid Leukemia, Including AML‐M4 and AML‐M5, Treated With Venetoclax Plus Azacitidine

American Journal of Hematology, EarlyView.
Marina Konopleva, Courtney D. DiNardo, Yan Sun, Paul Jung, Sanam Loghavi, Jalaja Potluri, Monique Dail, Brenda Chyla, Daniel A. Pollyea   +8 more
wiley   +1 more source

Targeting the MAPK Pathway in Brain Tumors: Mechanisms and Therapeutic Opportunities. [PDF]

Cancers (Basel)
Vrachas D, Kosma E, Giannopoulou AI, Margoni A, Gargalionis AN, El-Habr EA, Piperi C, Adamopoulos C.   +7 more
europepmc   +1 more source

Pancreatic cancer: molecular pathogenesis and emerging therapeutic strategies. [PDF]

Signal Transduct Target Ther
Rozengurt E, Eibl G.
europepmc   +1 more source

Mechanistic Consequences of Piezo1 Gain‐of‐Function Variants for Decreased Red Cell Survival in Hereditary Xerocytosis

American Journal of Hematology, EarlyView.
Asya Makhro, Rick Huisjes, Elena Seiler, Min Qiao, Marije Bartels, Inga Hegemann, Patrick Eppenberger, Nicole Bender, Isabel Dorn, Anna Bogdanova, Richard van Wijk, Lars Kaestner   +11 more
wiley   +1 more source

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Ras protein signalling

Seminars in Immunology, 2000
Ras proteins were identified through their association with cell transformation. Since then they have been shown to regulate cell growth, differentiation and apoptosis, as well as influencing processes such as cell migration and neuronal activity. Ras regulates a number of signalling molecules by translocating them to the plasma membrane for activation.
M F, Olson, R, Marais
openaire   +2 more sources

Ras-related proteins

Current Opinion in Cell Biology, 1993
A combination of genetic and biochemical techniques has revealed key players in the Ras signal transduction pathway that link receptors to growth and differentiation. Rho and Rac have been shown to couple extracellular signals to the organization of the actin cytoskeleton, while ADP ribosylation factor is required for the formation of non-clathrin ...
openaire   +2 more sources

Isoprenoids Influence Expression of Ras and Ras-Related Proteins

Biochemistry, 2002
Mevalonate depletion by inhibition of hydroxymethylglutaryl coenzyme A reductase impairs post-translational processing of Ras and Ras-related proteins. We have previously shown that this mevalonate depletion also leads to the upregulation of Ras, Rap1a, RhoA, and RhoB.
Sarah A, Holstein, Christine L, Wohlford-Lenane, Raymond J, Hohl   +2 more
openaire   +2 more sources