Results 111 to 120 of about 3,724,057 (366)

Sequence homology between RNAs encoding rat α-fetoprotein and rat serum albumin [PDF]

open access: yes, 1981
We have determined the sequences of the recombinant DNA inserts of three bacterial plasmid cDNA clones containing most of the rat α-fetoprotein mRNA. The resultant nucleotide sequence of α-fetoprotein was exhaustively compared to the nucleotide sequence ...
Bonner, James   +4 more
core  

NanoCMSer: a consensus molecular subtype stratification tool for fresh‐frozen and paraffin‐embedded colorectal cancer samples

open access: yesMolecular Oncology, EarlyView.
Consensus molecular subtypes (CMS1‐4) have been identified to study colorectal cancer heterogeneity and serve as potential biomarkers. In this study, we developed and evaluated NanoCMSer, a NanoString‐based classifier using 55 genes, optimized for FF and FFPE to facilitate the clinical evaluation of CMS subtyping.
Arezo Torang   +10 more
wiley   +1 more source

Comparative Analysis of Reinforcement Learning Algorithms for Bipedal Robot Locomotion

open access: yesIEEE Access
In this research, an optimization methodology was introduced for improving bipedal robot locomotion controlled by reinforcement learning (RL) algorithms.
Omur Aydogmus, Musa Yilmaz
doaj   +1 more source

The emergence of tool use in preterm infants

open access: yesFrontiers in Psychology, 2016
Preterm born children without neurological impairments have been shown to present some visual-manual coordination deficits, more or less depending on their tonicity and the degree of prematurity.
Maja Petkovic   +2 more
doaj   +1 more source

Robust acute myeloid leukemia engraftment in humanized scaffolds using injectable biomaterials and intravenous xenotransplantation

open access: yesMolecular Oncology, EarlyView.
Patient‐derived xenografts (PDXs) can be improved by implantation of a humanized niche. We tested different biomaterials and approaches, and demonstrate that the combination of an injectable biomaterial for scaffold creation plus an intravenous route for acute myeloid leukemia (AML) xenotransplantation provide the most convenient and robust approach to
Daniel Busa   +13 more
wiley   +1 more source

Functional Magnetic Resonance Imaging: a study of malnourished rats [PDF]

open access: yesarXiv, 2013
Malnutrition is a main public health problem in developing countries. Incidence is increasing and the mortality rate is still high. Malnutrition can leads mayor problems that can be irreversible if it is present before brain development is completed. We used BOLD (blood oxygen level-dependent effect) Functional Magnetic Resonance Imaging to investigate
arxiv  

KMT2A degradation is observed in decitabine‐responsive acute lymphoblastic leukemia cells

open access: yesMolecular Oncology, EarlyView.
We demonstrate that decitabine (DEC) not only degrades the DNA methyltransferase DNMT1 but also the leukemic driver lysine methyltransferase KMT2A likely due to structural similarity of the DNA‐binding CXXC domains. DEC influences KMT2A downstream processes and synergizes with menin inhibitor revumenib (REV) to decrease leukemic cell proliferation, and
Luisa Brock   +10 more
wiley   +1 more source

Plague of Rats [PDF]

open access: yesNature, 1879
I SEE by NATURE, vol. xx. p. 65, that Mr. Orville A. Derby contributes some very interesting information relating to a plague of rats in Brazil, and adding that the plague “is said to occur at intervals of about thirty years, and to be simultaneous with the drying of the Taguara, or bamboo, which everywhere abounds in the Brazilian forests.” It may be ...
openaire   +2 more sources

Inhibition of acyl‐CoA synthetase long‐chain isozymes decreases multiple myeloma cell proliferation and causes mitochondrial dysfunction

open access: yesMolecular Oncology, EarlyView.
Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy   +12 more
wiley   +1 more source

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